ArticleChronic diseases and translational medicine2026
The Effect of the MTHFR C677T Genotype Polymorphism on the Efficacy of Folic Acid Treatment for Hyperhomocysteinemia and Cardiovascular Endothelial Function.
Article in Chronic diseases and translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cardiovascular disease remains a major public health burden. This study aimed to investigate the effect of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype on folic acid treatment response and cardiovascular endothelial function in patients with hyperhomocysteinemia (HHcy). Methods: We retrospectively enrolled 344 patients with HHcy genotyped for MTHFR C677T (CC, Results: After treatment, the Hcy concentration and pulse wave velocity decreased over time in all genotype groups, whereas the ankle-brachial index increased. Significant main effects of time were observed for Hcy concentration ( Conclusion: MTHFR C677T polymorphism significantly affects folic acid efficacy and endothelial improvement. Patients with the TT genotype had lower therapeutic efficacy of folic acid therapy. Genotyping may help estimate treatment responses and support individualized follow-up.
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