ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Optic disc drusen prevalence and visual outcome in a cohort of patients with non-arteritic anterior ischemic optic neuropathy.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
objectiveNon-arteritic anterior ischemic optic neuropathy (NAION) in younger patients is frequently associated with optic disc drusen (ODD), with reported prevalence exceeding 50%. The prevalence and clinical significance of ODD in patients aged 50 years and older remain unclear.
methodsWe analyzed data from the QRK207 trial of acute NAION. Spectralis SD-OCT scans from study and fellow eyes were reviewed at presentation and 6 months for ODD. Visual function was assessed using best-corrected visual acuity (BCVA) and average censored total deviation (avgTD). Associations were evaluated using t-tests and Fisher exact tests.
resultsAt presentation, we identified ODD in 3.6% (13/360) of study eyes and 4.2% (12/283) of fellow eyes without prior NAION. At 6 months, ODD were present in 5.7% (17/296) of study eyes. Eyes with ODD had worse avgTD at presentation than eyes without ODD (-9.5 ± 3.4 dB vs. -7.9 ± 2.7 dB; p = 0.03). At 6 months, avgTD did not differ between groups (-9.5 ± 3.0 dB vs. -9.0 ± 3.0 dB; p = 0.45). There were no significant differences in VF progression (8% vs. 21%; p = 0.48) or BCVA at presentation (p = 0.06) or 6 months (p = 0.99).
conclusionsODD were found in a relatively small proportion of older patients with NAION. Although associated with worse visual field loss at presentation, ODD do not appear to influence visual recovery or progression and are not a major determinant of disease severity or outcome.
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