Nonenzymatic detection and imaging of m6A-methylated RNA via proximity hybridization-initiated hybridization chain reaction with site-specific recognition.

Liang Xu, Mengru Li, Siyong Zhang, Yujie Wang, Xiaoyan Dai, Ying Chen, Hongmei Fu, Zhifa Shen, Shihao Xu

Abstract read

In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liang XuKey Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, 325035, China.

Mengru LiDepartment of Ultrasound Medicine, Wenzhou Key Laboratory of Interventional Ultrasound for Intelligent Healthcare and Clinical Translation, National Key Clinical Specialty (Wound Healing), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Siyong ZhangKey Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, 325035, China.

Yujie WangKey Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, 325035, China.

Xiaoyan DaiKey Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, 325035, China.

Ying ChenKey Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, 325035, China.

Hongmei FuKey Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, 325035, China.

Zhifa ShenKey Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou, 325035, China. shenzhifa@wmu.edu.cn.

Shihao XuDepartment of Ultrasound Medicine, Wenzhou Key Laboratory of Interventional Ultrasound for Intelligent Healthcare and Clinical Translation, National Key Clinical Specialty (Wound Healing), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. dcxshvip@wmu.edu.cn.

Funding

Basic Scientific Research Project of Wenzhou Y20240967Key Research and Development Program of Zhejiang Province 2021C03003

6 · The paper itself

Abstract

Indexed as

In situ imagingm6A detectionProximity hybridization-initiated hybridization chain reaction (PH-HCR)Single-cell resolution

Identifiers

PMID42853389

DOI10.1021/acs.analchem.4c01992

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.