ArticleNeuroinformatics2026
Testing the Transferability of Perturbational Similarity Maps Across Species, Cell Systems, and Assay Modalities.
Article in Neuroinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
We evaluated a mouse whole-brain perturbation map in human K562 and RPE1 Perturb-seq, HeLa morphology and nine L1000 cell-line matrices using three endpoints: global pair-rank concordance, source-defined top-k neighbour preservation, and within-validation CORUM retrieval. Strict orthology retained 71, 90, 695 and 273-311 shared targets, respectively. Under the primary zero-anchored RMS representation, Spearman rho was 0.026 and 0.035 in K562 and RPE1, 0.0022 and 0.0055 in the two HeLa conditions, and a median of 0.0055 across L1000 lines. RPE1 depended on representation: across-target standardisation gave rho = 0.102 (95% CI, 0.027-0.201), whereas omitting feature RMS scaling gave a descriptive rho = -0.034. No source-defined top-10 neighbour preservation result survived correction across 13 contexts (minimum q = 0.240). Source pair ranks also changed when response features were restricted. Within-validation CORUM retrieval identified complex structure in several external matrices but did not test preservation of source neighbours. Across 50 cell splits, K562/RPE1 median global rho was 0.600/0.710 and top-10 overlap was 0.497/0.517. Across 50 mouse-level splits of K562/RPE1-matched source profiles, median global rho was 0.731/0.703; a cross-species noise ceiling remains unestimated. The results are conditional on representation and feature selection and do not establish absence of transfer or transferability to neural systems.
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