ArticlePloS one2026
Transcriptomic analysis of zebrafish (Danio rerio) liver exposed to sediments from the Loa River.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal(loid) contamination in aquatic ecosystems, particularly the Loa River in Chile, poses significant environmental and health challenges. This study investigated the molecular impacts of such contamination by exposing zebrafish (Danio rerio) to sediments from pre-impact and severely impacted zones of the Loa River, utilizing transcriptomic analysis of zebrafish liver. Sediment characterization confirmed arsenic as the main driver of contamination, with As concentrations significantly higher at La Finca. Our findings reveal a clear and distinct cascade of molecular responses in fish exposed to impacted sediments, which provides evidence for an Adverse Outcome Pathway. This AOP commences with Molecular Initiating Events, including significant differential expression of genes related to metal adsorption and homeostasis (slc31a1, slc40a1; FDR-adjusted q < 0.05; p < 0.05 for IT7 vs C0 and IT7 vs PIT7), signifying direct perturbations in intracellular metal regulation. This is followed by Key Events characterized by heightened cellular stress, evidenced by significant upregulation of xbp1, xbp1a, xbp1b, and hsp90a/hspd1 (IT7 vs C0; p < 0.05), consistent with oxidative stress and endoplasmic reticulum dysfunction, as well as hypoxia-like conditions. Progressing further, significant differential expression of angiogenesis-related genes (ptprb, mib1, adam10a, foxc1a; p < 0.05) suggests activation of tissue remodeling processes. The cascade culminates in alterations of genes associated with early carcinogenic signaling, including epigenetic regulation (hdac1) and genomic instability (rassf1, top2b; FDR q < 0.05; p < 0.05). This research demonstrates the power of transcriptomics to differentiate the biological impact of contaminated sediments from pre-impact conditions, offering a detailed molecular fingerprint of sublethal effects crucial for identifying early warning signals of environmental degradation and understanding potential human health impacts.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.