Evidence map›Paper›PMID 42855600›Full record

ArticleNature aging2026

Lymph node contraction links sex-biased naive CD8

Lutz Menzel, Maria Zschummel, Meghan J O'Melia, Mårten Sandstedt, Hengbo Zhou, Pin-Ji Lei, Lingshan Liu, Hang Lee, Debattama R Sen, Lance L Munn and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lutz MenzelEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. lmenzel1@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-3816-6255
Maria ZschummelDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4778-8742
Meghan J O'MeliaEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mårten SandstedtDepartment of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.ORCID http://orcid.org/0000-0002-0973-9499
Hengbo ZhouEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9948-7909
Pin-Ji LeiEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Lingshan LiuEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hang LeeBiostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Debattama R SenDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0947-8284
Lance L MunnEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Lena JonassonDepartment of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Timothy P PaderaEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. tpadera@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-3453-9384

Funding

Systems biology of lymphatic transportR01HL128168 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MUNN, LANCE L., PADERA, TIMOTHY P · 2015 to 2019
$2.9M
Targeting lymph node metastases to prevent cancer progressionR01CA214913 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PADERA, TIMOTHY P · 2017 to 2022
$2.0M
Targeting lymph node metastases to block cancer progressionR01CA284372 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI TIMOTHY P PADERA · 2023 to 2026
$2.0M
Systems Biology of Antigen and T-Cell Transport in Cancer ImmunotherapyR01CA284603 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Lance L. Munn, TIMOTHY P PADERA · 2023 to 2026
$1.9M
Reversing aging-induced lymphatic dysfunction to improve immune functionR21AG072205 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI PADERA, TIMOTHY P · 2022 to 2023
$458k
A mechanistic dissection of the role of Eya3 in breast cancer metastasisK00CA234940 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI ZHOU, HENGBO · 2020 to 2023
$405k
Enhanced antigen-lymphocyte interactions to improve immune checkpoint blockade in breast cancerF32CA275298 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI O'MELIA, MEGHAN · 2022 to 2024
$213k
Deutsche Forschungsgemeinschaft (German Research Foundation) ME 5486/1-2Deutsche Forschungsgemeinschaft (German Research Foundation) ME 5486/2-1Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) DP2 AI176139Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) U19 AI082630Hjärt-Lungfonden (Swedish Heart-Lung Foundation) 20180436U.S. Department of Health & Human Services | National Institutes of Health (NIH) F32CA275298U.S. Department of Health & Human Services | National Institutes of Health (NIH) K00CA234940U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA214913U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA284372U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01CA284603U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL128168U.S. Department of Health & Human Services | National Institutes of Health (NIH) R21AG072205Vetenskapsrådet (Swedish Research Council) 2018-03232
6 · The paper itself

Abstract

The abundance of diverse naive CD8

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.