ArticleFrontiers in medicine2026
Comparative efficacy of intra-articular polynucleotide injection combined with rehabilitation therapy in knee osteoarthritis with and without diabetes mellitus and construction of a nomogram: a propensity score-matched cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To compare the longitudinal clinical efficacy of intra-articular polynucleotide (PN) injection combined with prescribed rehabilitation therapy in patients with knee osteoarthritis (KOA) with and without type 2 diabetes mellitus (T2DM), to investigate the influence of glycemic control on treatment outcomes, and to construct a predictive model. Methods: A total of 458 patients with KOA who received PN combined with rehabilitation therapy were retrospectively enrolled. After 1:2 propensity score matching (PSM), 270 patients were included (90 in the diabetes mellitus [DM] group and 180 in the non-DM group). Generalized estimating equations (GEE) were used to compare the longitudinal trajectories of Visual Analog Scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores between the two groups. Stratified analyses were further performed within the DM subgroup according to baseline glycated hemoglobin (HbA1c) levels. Least absolute shrinkage and selection operator (LASSO) regression combined with multivariable Logistic regression was used to construct a nomogram predicting the probability of achieving Patient Acceptable Symptom State (PASS) at 6 months. Results: After matching, no significant differences were observed between the two groups in the improvement trajectories of VAS and WOMAC scores (group effect, Conclusion: Among patients with KOA receiving intra-articular PN injection together with a prescribed rehabilitation program, those with T2DM showed 6-month clinical outcome trajectories comparable to those without DM. Good glycemic control and favorable rehabilitation adherence are key factors for optimizing therapeutic outcomes.
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