ArticleHealth science reports2026
Retrospective Cohort Study on the Association Between a Laboratory Test-Derived Frailty Index and Mortality in Elderly Critically Ill Patients With Chronic Kidney Disease.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background/Aims: Chronic kidney disease (CKD) represents a growing worldwide health concern. There is a need for easily obtainable markers that can improve risk evaluation in affected patients. Here, we investigated whether a laboratory-derived frailty index (FI-Lab) carries prognostic information for older CKD individuals admitted to intensive care. Methods: A retrospective cohort design was adopted, drawing on the MIMIC-IV repository. Records of elderly ICU patients with diagnosed CKD were retrieved. The endpoints of interest were all-cause death within 30 and 90 days. Cox proportional hazards regression with incremental covariate adjustment and propensity score matching were employed to quantify the independent contribution of FI-Lab to survival. Results: The analytic sample consisted of 5013 hospitalized CKD patients (mean age 77.9 ± 7.6 years; 61.4% male). Following full adjustment, a 0.1-unit rise in FI-Lab corresponded to a 94% higher mortality risk at 30 days (HR 1.94; 95% CI 1.57-2.40) and a 65% higher risk at 90 days (HR 1.65; 95% CI 1.43-1.91; both Conclusions: An elevated FI-Lab score at ICU entry is independently tied to elevated short- and intermediate-term mortality in older critically ill patients with CKD. Confirmatory prospective work is needed to establish its clinical role in this population.
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