Evidence map›Paper›PMID 42864640›Full record

ArticleJournal of translational medicine2026

Single-cell transcriptomics reveals transcriptional reprogramming and microenvironmental remodeling in ectopic ACTH/CRH-secreting pheochromocytomas.

Wan Su, Shiwei Chen, Jinghua Liu, Penghu Lian, Xuebin Zhang, Yushi Zhang, Wencong Han, Qi Shen, Di Zhang, Xiang Zhou and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wan Su *Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Shiwei Chen *Department of Urology, Peking University First Hospital, Institution of Urology, Peking University, Beijing Key Laboratory of Precision Medicine and Innovative Translation for Urogenital Diseases, National Urological Cancer Center, Beijing, 100034, China.
Jinghua Liu *Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Penghu LianDepartment of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Xuebin ZhangDepartment of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Yushi ZhangDepartment of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Wencong HanDepartment of Urology, Peking University First Hospital, Institution of Urology, Peking University, Beijing Key Laboratory of Precision Medicine and Innovative Translation for Urogenital Diseases, National Urological Cancer Center, Beijing, 100034, China.
Qi ShenDepartment of Urology, Peking University First Hospital, Institution of Urology, Peking University, Beijing Key Laboratory of Precision Medicine and Innovative Translation for Urogenital Diseases, National Urological Cancer Center, Beijing, 100034, China.
Di ZhangKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Xiang ZhouKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Yu XiaoDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Qing LingDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Ying GaoDepartment of Endocrinology, Peking University First Hospital, Beijing, 100034, China.
Lin LuKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. lulin@pumch.cn.
Zheng ZhangDepartment of Urology, Peking University First Hospital, Institution of Urology, Peking University, Beijing Key Laboratory of Precision Medicine and Innovative Translation for Urogenital Diseases, National Urological Cancer Center, Beijing, 100034, China. doczhz@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEctopic ACTH- and/or CRH-secreting pheochromocytomas (ACTH

methodsFresh tumor specimens from three ACTH

resultsACTH

conclusionsOur study provides single-cell insights into the tumor-intrinsic and microenvironmental heterogeneity between ACTH

Indexed as

Adrenal Gland NeoplasmsAdrenocorticotropic HormoneCorticotropin-Releasing HormonePheochromocytomaSingle-Cell AnalysisTranscription, GeneticTranscriptomeTumor MicroenvironmentGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansSingle-Cell Gene Expression AnalysisAdrenocorticotropic HormoneCorticotropin-Releasing HormoneCEBPBEctopic ACTH/CRH secretingPheochromocytomasTumor microenvironment

Identifiers

PMID42864640
PMCPMC13660345

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.