ReviewJournal of inflammation research2026
Zebrafish Models of Arthritis and Their Applications in Traditional Chinese Medicine Screening: Advances and Perspectives.
Review in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The zebrafish is a widely utilized model organism in medical research because of its high reproductive capacity, rapid development, transparent embryos, genetic tractability, and similarity to humans in skeletal development. In this review, we searched CNKI and PubMed up to July 30, 2026 using combinations of "zebrafish", "arthritis", "osteoarthritis", "rheumatoid arthritis", "gouty arthritis", "infectious arthritis", "traditional Chinese medicine", and "natural products". Both Chinese and English articles were considered. A total of 67 articles were initially retrieved. After manual screening against the inclusion criteria, the most relevant studies were selected for this review. Studies were reviewed when they described zebrafish arthritis-related models, inflammatory or skeletal phenotypes, or TCM/natural product screening. Current research has applied zebrafish models mainly to osteoarthritis (OA) and rheumatoid arthritis (RA), while infectious and gouty arthritis models remain less developed. These models help elucidate pathogenic genes associated with OA, evaluate induced OA-like pathology, explore immune and vascular mechanisms in RA, simulate acute gout-related innate inflammation, and investigate host-pathogen responses relevant to infectious arthritis. Compared with previous reviews, this review specifically addresses the application of zebrafish arthritis models in traditional Chinese medicine (TCM) screening, with emphasis on model classification and current limitations. TCM compounds and formulas can be evaluated in zebrafish through whole-organism phenotypes including inflammatory-cell recruitment, angiogenesis, toxicity, and drug-response patterns. These findings demonstrate anti-angiogenic activities that may be relevant to arthritis, but they do not establish therapeutic efficacy against arthritis itself. Future studies should further refine zebrafish models for specific arthritis types, report strain background and dose more consistently, and validate larval screening results in adult zebrafish or mammalian models when possible, as zebrafish are complementary screening models that cannot fully reproduce all aspects of adult human arthritis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.