Evidence map›Paper›PMID 42867528›Full record

ArticlePsychopharmacology2026

Acute anxiogenic effects of psilocybin and the related tryptamine, norbaeocystin, in male and female rats.

Marisa J Savini, Kylie M King, Lillianna P Puppel, Aleece K Al-Olimat, Noelle M Molnar, Evelynn J Schneider, Savannah E Straub, Joe Parker, Colin J Gottron, Allison M Bach and 6 more

Abstract read
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In one paragraph

Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Marisa J SaviniDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Kylie M KingDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Lillianna P PuppelDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Aleece K Al-OlimatDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Noelle M MolnarDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Evelynn J SchneiderDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Savannah E StraubDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Joe ParkerDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Colin J GottronDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Allison M BachDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Solomon M LambdinDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Stephanie M ReganDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Kaitlyn E WilliamsDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
Troy R WelkerDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA.
J Andrew JonesDepartment of Chemical, Paper, and Biomedical Engineering, Miami University, 501 E. High St, Oxford, OH, 45056, USA.
Phillip R ZoladzDepartment of Psychology and Education, The School of Health, Life Sciences, and Education, Ohio Northern University, 525 S. Main St, Ada, OH, 45810, USA. p-zoladz@onu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationalePsychedelics are considered to be promising therapeutic agents that could effectively treat several psychological disorders. However, these compounds can exert acute adverse effects that limit their practicality.

objectivesAcross three experiments, the present study examined the acute and delayed effects of psilocybin (PSIL) and its putatively non-hallucinogenic analog, norbaeocystin (NOR), on anxiety-like behavior and the influence of the female estrous cycle on acute response to the compounds.

methodsIn Experiment 1, rats were treated with PSIL or NOR (0.3-1 mg/kg) and tested on the elevated plus maze (EPM) or open field 30 min later. In Experiment 2, male and female rats were treated with 1 mg/kg PSIL or NOR and tested on the EPM 24 h later. In Experiment 3, we tracked the female estrous cycle to determine whether it was associated with the acute effects of PSIL or NOR on EPM behavior and the acoustic startle response (ASR).

resultsIn Experiment 1, both PSIL and NOR exerted acute anxiogenic effects in males, while only the highest dose of PSIL increased anxiety-like behavior in females. In Experiment 2, neither PSIL nor NOR impacted EPM behavior the next day. In Experiment 3, PSIL, but not NOR, had acute anxiogenic effects on EPM behavior, effects that were independent of estrous stage. Females treated with PSIL during diestrus exhibited some signs of greater ASR habituation.

conclusionsPSIL and NOR exerted transient dose- and sex-specific effects on anxiety-like behavior, which may inform their use as novel therapeutics.

Indexed as

AnxietyEstrousNorbaeocystinPsilocybinPsychedelicsSex differences

Identifiers

PMID42867528

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.