Evidence map›Paper›PMID 42871244›Full record

ReviewCVIR oncology2026

Understanding histotripsy ablation safety: a systematic review of pre-clinical and clinical adverse events.

Madeline I Foo, Cynthia Uzoukwu, Robert Morhard, Katrina L Falk, Bradford J Wood, Gregory Frey, Timothy J Ziemlewicz, Eli Vlaisavljevich, Beau B Toskich, Alissa Hendricks-Wenger

Abstract readReview
In one paragraph

Review in CVIR oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Madeline I FooDepartment of General Surgery, Johns Hopkins Hospital University, Baltimore, MD USA.
Cynthia UzoukwuNortheastern Ohio Medical University, Rootstown, OH USA.
Robert MorhardCenter for Interventional Oncology, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD USA.
Katrina L FalkDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI USA.
Bradford J WoodDepartment of Oncology and Department of Radiology, University of Milan, Milan, Italy.
Gregory FreyDivision of Interventional Radiology, Mayo Clinic Florida, Jacksonville, FL USA.
Timothy J ZiemlewiczDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI USA.
Eli VlaisavljevichDepartment of Biomedical Engineering & Mechanics, Virginia Tech, Blacksburg, VA USA.
Beau B ToskichDivision of Interventional Radiology, Mayo Clinic Florida, Jacksonville, FL USA.
Alissa Hendricks-WengerDivision of Interventional Radiology, Mayo Clinic Florida, Jacksonville, FL USA.ORCID 0000-0001-8561-8288

Funding

Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Developing an Accurate and Robust Targeting Technique to Enable Transcostal Histotripsy Treatment of Liver TumorsF30CA284541 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Katrina Lauren Falk · 2024 to 2026
$135k
NCI NIH HHS F30 CA284541NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

Histotripsy is the first cavitation-based ablation modality. Given limited clinical experience, synthesis of pre-clinical and early clinical data is essential to guide safe adoption. A PubMed and SCOPUS search was performed focused on pre-clinical and clinical adverse events (AEs) from Histotripsy ablation of parenchymal tissues in vivo (

Indexed as

AblationAdverse eventsComplicationsFocused ultrasoundHistotripsySafety

Identifiers

PMID42871244
PMCPMC13658349

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.