Evidence map›Paper›PMID 42871983›Full record

ArticleResearch and practice in thrombosis and haemostasis2026

Outcomes of hemophilia A in children under primary and secondary prophylaxis: results from the HEMFIL Cohort Study.

Patrícia Santos Resende Cardoso, Márcio Antônio Portugal Santana, Eder Luciano Vaz Dos Santos, Camila Beatriz Pereira Gomes da Silva, Brisa Yuan Renó, Leonardo Fontenelle de Carvalho, Suely Meireles Rezende

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Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Patrícia Santos Resende CardosoHematology and Oncology Unit, University Hospital, University Federal of Minas Gerais, Belo Horizonte, Brazil.
Márcio Antônio Portugal SantanaHematology, Fundação Centro de Hematologia e Hemoterapia do Estado de Minas Gerais (Fundação Hemominas), Minas Gerais, Belo Horizonte, Brazil.
Eder Luciano Vaz Dos SantosFundação Centro de Hematologia e Hemoterapia do Estado de Minas Gerais (Fundação Hemominas), Minas Gerais, Brazil.
Camila Beatriz Pereira Gomes da SilvaFaculty of Medicine, University Federal of Minas Gerais, Belo Horizonte, Brazil.
Brisa Yuan RenóFaculty of Medicine, University Federal of Minas Gerais, Belo Horizonte, Brazil.
Leonardo Fontenelle de CarvalhoDepartment of Radiology Medicine, University Hospital, University Federal of Minas Gerais, Belo Horizonte, Brazil.
Suely Meireles RezendeDepartment of Internal Medicine, Faculty of Medicine, University Federal of Minas Gerais, Belo Horizonte, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Early prophylaxis reduces the risk of joint damage in children with hemophilia A (CwHA). Long-term comparative data on bleeding outcomes and joint health in CwHA under primary prophylaxis (PP) and secondary prophylaxis (SP) remain limited. Methods: This prospective cohort study enrolled previously untreated or minimally treated (<5 exposure days) CwHA (factor VIII < 0.02 IU/mL). Patients were followed until 75 exposure days or inhibitor development. Annual bleeding rate (ABR) and annual joint bleeding rate (AjBR) were evaluated before and after prophylaxis initiation. Joint status was assessed once, at a median patient age of 8.4 years, using the Haemophilia Early Arthropathy Detection with Ultrasound and the Haemophilia Joint Health Score. Results: A total of 43 children were included (PP, Conclusion: In this study, CwHA receiving PP appeared to have a more severe bleeding phenotype compared with those on SP. However, this requires confirmation in future studies. Long-term joint outcomes were generally mild.

Indexed as

Factor VIIIHemarthrosisHemophilia AAdolescentChildChild, PreschoolFemaleHemorrhageHumansMaleProspective StudiesRisk FactorsSecondary PreventionTime FactorsTreatment OutcomeF8 protein, humanFactor VIIIHEAD-UShemophilia AHJHSprimary and secondaryprophylaxis

Identifiers

PMID42871983
PMCPMC13659758

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.