ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2026
Association of body roundness index with incidence of chronic kidney disease: A prospective cohort study in China.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Visceral adiposity drives chronic kidney disease (CKD) progression, but conventional anthropometric indices inadequately capture its risk. We aimed to evaluate the Body Roundness Index (BRI), a geometric measure of central adiposity, as a predictor of incident CKD in Asian populations, where evidence remains scarce. Materials and Methods: In this prospective analysis of 480,422 China Kadoorie Biobank participants without baseline CKD, BRI was calculated from waist circumference (WC) and body height using a validated formula. Incident CKD was ascertained through International Classification of Diseases, 10 Results: During follow-up, 2,737 incident CKD cases occurred. Each 1-unit increase in BRI conferred 19% higher CKD risk in fully adjusted models (HR: 1.19, 95% confidence interval: 1.13-1.25). A nonlinear (J-shaped) association emerged with significantly elevated risk above BRI ≈ 3.5 (P for nonlinearity = 0.067). Subgroup analyses revealed stronger associations in participants aged <60 years, higher socioeconomic status (≥¥20,000/year), current drinkers, hypertensives, and non-overweight individuals (body mass index [BMI] <24 kg/m Conclusion: BRI independently predicts CKD in Chinese adults, outperforming conventional indices and identifying high-risk phenotypes missed by BMI. The nonlinear association with threshold at BRI ≈ 3.5 offers a practical tool for population screening, particularly valuable for early intervention in resource-limited settings.
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