Evidence map›Paper›PMID 42875583›Full record

ArticleNature aging2026

Senescent-like activated naive B cells contribute to progression to clinical rheumatoid arthritis.

Xiaohao Wu, Mengrui Zhang, Jae-Seung Moon, Eun Kyung Song, Joshua C Abrams, Laura S van Dam, Orr Sharpe, Zhen Wang, Marie L Feser, Laurakay Moss and 13 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Xiaohao Wu *Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0984-7414
Mengrui Zhang *Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7082-3753
Jae-Seung Moon *Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1983-465X
Eun Kyung SongDivision of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.
Joshua C AbramsDivision of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0009-0009-6712-3551
Laura S van DamDivision of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.
Orr SharpeDivision of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.
Zhen WangDivision of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.
Marie L FeserDivision of Rheumatology, University of Colorado Anschutz, Aurora, CO, USA.
Laurakay MossDivision of Rheumatology, University of Colorado Anschutz, Aurora, CO, USA.
Peggy P HoDepartment of Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA.
Melanie H SmithHospital for Special Surgery and Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2464-8429
Laura T DonlinHospital for Special Surgery and Weill Cornell Medicine, New York, NY, USA.
Jane H BucknerCenter for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.
Eddie A JamesCenter for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.
Gary S FiresteinDivision of Rheumatology, Autoimmunity and Inflammation, UC San Diego School of Medicine, San Diego, CA, USA.
Yuko OkamotoDivision of Rheumatology, University of Colorado Anschutz, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-8088-1746
Tobias V LanzDivision of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.
Eric MeffreDivision of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.
Aiping LyuInstitute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-2303-0494
V Michael HolersDivision of Rheumatology, University of Colorado Anschutz, Aurora, CO, USA.
Kevin D DeaneDivision of Rheumatology, University of Colorado Anschutz, Aurora, CO, USA.
William H RobinsonDivision of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA. w.robinson@stanford.edu.ORCID http://orcid.org/0000-0003-4385-704X

Funding

Core 2 - Mucosal Immunobiology Core (MIC)P30AR079369 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Vernon Michael Holers · 2021 to 2026
$4.7M
Investigating Mucosal Breaks in the Initiation and Progression of Rheumatoid ArthritisR01AR078268 · NIAMS · STANFORD UNIVERSITY · PI ORANGE, DANA ELIZABETH, ROBINSON, WILLIAM H · 2021 to 2025
$3.1M
U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30 AR079369U.S. Department of Health & Human Services | National Institutes of Health (NIH) PATHO-PH2-SUB_17_23U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01 AI173189-01U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01 AR078268
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease marked by joint and systemic inflammation. Anticitrullinated protein antibodies identify an at-risk stage that precedes clinical RA, yet the mechanisms driving disease progression remain poorly understood. Here we show that anticitrullinated-protein-antibody-positive individuals who progressed to RA exhibited a marked expansion of CXCR5

Indexed as

Arthritis, RheumatoidB-LymphocytesCellular SenescenceLymphocyte ActivationAnti-Citrullinated Protein AntibodiesAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensDisease ProgressionFemaleHumansLectins, C-TypeMaleMiddle AgedReceptors, CXCR5Synovial MembraneAnti-Citrullinated Protein AntibodiesAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensCXCR5 protein, humanLectins, C-TypeReceptors, CXCR5

Identifiers

PMID42875583

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.