ArticleFrontiers in reproductive health2026
Investigation into biomarkers to predict preterm birth (INSIGHT): a longitudinal UK pregnancy cohort for spontaneous preterm birth research.
Article in Frontiers in reproductive health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Spontaneous preterm birth (sPTB) remains a leading cause of perinatal morbidity and mortality worldwide. Progress in prediction and prevention has been limited by the biological heterogeneity of sPTB and a lack of longitudinal pregnancy cohorts integrating detailed clinical phenotyping with serial biological sampling. The INSIGHT study was established to enable mechanistic and biomarker-driven investigation of sPTB, with a focus on inflammatory pathways associated with cervical shortening. Methods: INSIGHT is a prospective, multicentre UK pregnancy cohort that was active between 2013 and 2024 (recruitment finished in 2023). Pregnant women were recruited between 10 Results: A total of 2,272 women were enrolled and completed the study, spanning a broad sociodemographic background and risk spectrum, with 1,317 (58%) classified as high-risk of preterm birth. The cohort captured a high incidence of sPTB in singleton pregnancies ( Conclusion: INSIGHT provides a large, deeply phenotyped pregnancy cohort enriched for sPTB, integrating longitudinal clinical data with serial multiomic biological sampling. The study infrastructure supports discovery-driven and translational research into the mechanisms underlying sPTB and the development and independent validation of clinically scalable biomarker-based prediction strategies.
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