ArticleThe clinical respiratory journal2026
Development and Internal Validation of a Prediction Model Incorporating Respiratory Muscle Function for CAT Score Deterioration in Stable COPD.
Article in The clinical respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe objectives are to investigate the association between respiratory muscle function and CAT score deterioration in stable chronic obstructive pulmonary disease (COPD) and to develop an internally validated prediction model.
methodsThis single-center retrospective cohort study included 203 patients with stable COPD. Clinically significant CAT score deterioration was defined as an increase of ≥ 2 points from baseline within 12 months. Predictors were selected using LASSO Cox regression and incorporated into a multivariable Cox model. Model performance and the incremental value of maximal inspiratory pressure (MIP) and diaphragm thickening fraction (DTF) were evaluated.
resultsDuring follow-up, 62 patients (30.5%) experienced CAT score deterioration. Higher FEV
conclusionsLower MIP and DTF were independently associated with a higher risk of CAT score deterioration in stable COPD. Incorporating these parameters provided incremental predictive information beyond conventional clinical predictors. External validation is required.
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