ArticleThe American journal of physiology1982
Active and passive capillary control in red muscle at rest and in exercise.
Article in The American journal of physiology, 1982. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03883412 (Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes), which is not on this map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)
Who cites it
34 citing papers in PubMed.
- Candesartan acutely recruits skeletal and cardiac muscle microvasculature in healthy humans.The Journal of clinical endocrinology and metabolism · 2012Trial
- Insulin resistance and vasodilation in essential hypertension. Studies with adenosine.The Journal of clinical investigation · 1994Trial
- The physiologic power of fluid circulation and implications for fluid therapy.Frontiers in veterinary science · 2026Review
- Microvascular Skeletal-Muscle Crosstalk in Health and Disease.International journal of molecular sciences · 2023Review
- Capillary-Mitochondrial Oxygen Transport in Muscle: Paradigm Shifts.Function (Oxford, England) · 2023Review
- Diabetes pathogenesis and management: the endothelium comes of age.Journal of molecular cell biology · 2021Article
- Application of negative tissue interstitial pressure improves functional capillary density after hemorrhagic shock in the absence of volume resuscitation.Physiological reports · 2021Article
- GLP-1 and insulin regulation of skeletal and cardiac muscle microvascular perfusion in type 2 diabetes.Journal of diabetes · 2020Review
- Perfusion controls muscle glucose uptake by altering the rate of glucose dispersion in vivo.American journal of physiology. Endocrinology and metabolism · 2019Article
- Edward F. Adolph Distinguished Lecture. Contemporary model of muscle microcirculation: gateway to function and dysfunction.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Review
- Muscle Insulin Resistance and the Inflamed Microvasculature: Fire from Within.International journal of molecular sciences · 2019Review
- Muscle microvasculature's structural and functional specializations facilitate muscle metabolism.American journal of physiology. Endocrinology and metabolism · 2016Review
- Vascular function, insulin action, and exercise: an intricate interplay.Trends in endocrinology and metabolism: TEM · 2015Review
- Macular perfusion in healthy Chinese: an optical coherence tomography angiogram study.Investigative ophthalmology & visual science · 2015Article
- Adiponectin and insulin cross talk: the microvascular connection.Trends in cardiovascular medicine · 2014Review
- Treating Diabetes with Exercise - Focus on the Microvasculature.Journal of diabetes & metabolism · 2013Article
- Development of a new Sonovue™ contrast-enhanced ultrasound approach reveals temporal and age-related features of muscle microvascular responses to feeding.Physiological reports · 2013Article
- Capillary recruitment in a theoretical model for blood flow regulation in heterogeneous microvessel networks.Physiological reports · 2013Article
- Muscle-specific vascular endothelial growth factor deletion induces muscle capillary rarefaction creating muscle insulin resistance.Diabetes · 2013 · on this mapArticle
- Protein kinase A mediates glucagon-like peptide 1-induced nitric oxide production and muscle microvascular recruitment.American journal of physiology. Endocrinology and metabolism · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Capillary control was quantified in dog gracilis muscles from in situ. About 550 capillaries/mm2, one-third the total number present, were perfused with erythrocytes simultaneously at rest; two-thirds the total could be perfused during maximal vasodilation. The functional capillary reserve was about 600/mm2. Capillary distribution at rest reflects a passive, random process at individual capillaries and an active process that coordinates perfusion of small groups of capillaries. The latter creates long diffusion distances. These are unaltered by denervation, or flow per se, but are abolished by adenosine. Twitch contraction at 4/min recruited about 400 capillaries/mm2 without any change in flow. Capillaries opened selectively where diffusion distances were longest. The same changes occurred within 5 s during work at 4/s, even if flow was held constant. If flow could increase, about 200 additional capillaries/mm2 were slowly recruited, without change in capillary distribution. Conclusions are that 1) hemodynamics and active vasomotion contribute equally to capillary density at rest; 2) active papillary control in exercise is ungraded and solely responsible for eliminating metabolically significant diffusion paths; 3) flow and capillary density can be controlled independently by proximal and terminal arterioles, respectively.
Indexed as
Identifiers
7114231What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.