Metformin kinetics in healthy subjects and in patients with diabetes mellitus.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Who cites it

173 citing papers in PubMed, 4 syntheses or guidelines pooled it.

1. Comparison of the gamma-Pareto convolution with conventional methods of characterising metformin pharmacokinetics in dogs.Journal of pharmacokinetics and pharmacodynamics · 2020
   Pooled it
2. The Association between Metformin Therapy and Lactic Acidosis.Drug safety · 2019
   Pooled it
3. Is the use of metformin in patients undergoing dialysis hazardous for life? A systematic review of the safety of metformin in patients undergoing dialysis.British journal of clinical pharmacology · 2019
   Pooled it
4. Therapeutic Concentrations of Metformin: A Systematic Review.Clinical pharmacokinetics · 2016
   Pooled it
5. The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose-Dependent: A Three-Arm Crossover Study in Adults With Type 2 Diabetes.Clinical and translational science · 2025
   Trial
6. Bioequivalence of Metformin in Ertugliflozin/Metformin Fixed-Dose Combination Tablets to Canadian-Sourced Metformin Coadministered With Ertugliflozin Under Fasted and Fed States.Clinical pharmacology in drug development · 2021
   Trial
7. Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues.PloS one · 2021
   Trial
8. Effects of Pregnancy on the Pharmacokinetics of Metformin.Drug metabolism and disposition: the biological fate of chemicals · 2020 · on this map
   Trial
9. Bioequivalence of Ertugliflozin/Metformin Fixed-Dose Combination Tablets and Coadministration of Respective Strengths of Individual Components.Clinical pharmacology in drug development · 2020
   Trial
10. Improved glycemic control with minimal systemic metformin exposure: Effects of Metformin Delayed-Release (Metformin DR) targeting the lower bowel over 16 weeks in a randomized trial in subjects with type 2 diabetes.PloS one · 2018 · on this map
    Trial
11. Metformin and daclatasvir: absence of a pharmacokinetic-pharmacodynamic drug interaction in healthy volunteers.British journal of clinical pharmacology · 2017 · on this map
    Trial
12. 18F-FDG uptake in the colon is modulated by metformin but not associated with core body temperature and energy expenditure.PloS one · 2017
    Trial
13. Once-daily delayed-release metformin lowers plasma glucose and enhances fasting and postprandial GLP-1 and PYY: results from two randomised trials.Diabetologia · 2016 · on this map
    Trial
14. Measuring the biological effect of presurgical metformin treatment in endometrial cancer.British journal of cancer · 2016
    Trial
15. Bilayer matrix tablets for prolonged actions of metformin hydrochloride and repaglinide.AAPS PharmSciTech · 2015
    Trial
16. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.Pharmacogenetics and genomics · 2009
    Trial
17. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.Clinical pharmacology and therapeutics · 2008
    Trial
18. Steady-state pharmacokinetics of a novel extended-release metformin formulation.Clinical pharmacokinetics · 2005
    Trial
19. Effect of altered gastric emptying and gastrointestinal motility on metformin absorption.British journal of clinical pharmacology · 2000 · on this map
    Trial
20. The influence of dimethylbiguanide on phenprocoumon elimination and its mode of action. A drug interaction study.Klinische Wochenschrift · 1983
    Trial

113 more citing papers are in PubMed but not listed here.

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

6 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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