ArticleProceedings of the National Academy of Sciences of the United States of America1995
Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 139 citations in OpenAlex.
- Pathways to Parkinson's disease: a spotlight on 14-3-3 proteins.NPJ Parkinson's disease · 2021Review
- Tissue microarray profiling and integrative proteomics indicate the modulatory potential of Maytenus royleanus in inhibition of overexpressed TPD52 in prostate cancers.Scientific reports · 2021Article
- The role of 14-3-3 proteins in cell signalling pathways and virus infection.Journal of cellular and molecular medicine · 2021Review
- 14-3-3σ and Its Modulators in Cancer.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Excess active P13K rescues huntingtin-mediated neuronal cell death but has no effect on axonal transport defects.Apoptosis : an international journal on programmed cell death · 2019Article
- HIDEEP: a systems approach to predict hormone impacts on drug efficacy based on effect paths.Scientific reports · 2017Article
- Article
- 14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.Cell · 2013Article
- Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit.Oncogene · 2012Article
- Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling.The Journal of cell biology · 2008Article
- The role of stratifin in fibroblast-keratinocyte interaction.Molecular and cellular biochemistry · 2007Review
- DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding.Molecular biology of the cell · 2007Article
- A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.The Journal of experimental medicine · 2007Article
- A novel function of 14-3-3 protein: 14-3-3zeta is a heat-shock-related molecular chaperone that dissolves thermal-aggregated proteins.Molecular biology of the cell · 2006Article
- Immunocytochemical detection of 14-3-3 in primary nervous system tumors.Journal of neuro-oncology · 2006Article
- Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.Molecular and cellular biology · 2003Article
- Tenascin-C signaling through induction of 14-3-3 tau.The Journal of cell biology · 2003Article
- Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta.The Biochemical journal · 2003Article
- The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins.The Biochemical journal · 2002Article
- Structural and functional hot spots in cytokine receptors.International journal of hematology · 2001Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Proteins of the 14-3-3 family can associate with, and/or modulate the activity of, several protooncogene and oncogene products and, thus, are implicated in regulation of signaling pathways. We report that 14-3-3 is associated with another important transducing enzyme, phosphatidylinositol 3-kinase (PI3-K). A recombinant 14-3-3 fusion protein bound several tyrosine-phosphorylated proteins from antigen receptor-stimulated T lymphocytes. PI3-K was identified by immunoblotting and enzymatic assays as one of the 14-3-3-binding proteins in resting or activated cells. Moreover, endogenous 14-3-3 and PI3-K were coimmunoprecipitated from intact T cells. Far-Western blots of gel-purified, immunoprecipitated PI3-K with a recombinant 14-3-3 fusion protein revealed direct binding of 14-3-3 to the catalytic subunit (p110) of PI3-K. Finally, anti-phosphotyrosine immunoprecipitates from activated, 14-3-3-overexpressing cells contained lower PI3-K enzymatic activity than similar immunoprecipitates from control cells. These findings suggest that association of 14-3-3 with PI3-K in hematopoietic (and possibly other) cells regulates the enzymatic activity of PI3-K during receptor-initiated signal transduction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.