ReviewDrugs1994
The link between insulin resistance and hypertension. Effects of antihypertensive and antihyperlipidaemic drugs on insulin sensitivity.
Review in Drugs, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 29 citations in OpenAlex.
- The antihypertensive efficacy of losartan and amlodipine assessed with office and ambulatory blood pressure monitoring. Canadian Cozaar Hyzaar Amlodipine Trial Study Group.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1998Trial
- Association between eGDR and MASLD and liver fibrosis: a cross-sectional study based on NHANES 2017-2023.Frontiers in medicine · 2025Article
- Lipoic acid attenuates hypertension and improves insulin sensitivity, kallikrein activity and nitrite levels in high fructose-fed rats.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2004Article
- Prevention of type 2 diabetes mellitus through inhibition of the Renin-Angiotensin system.Drugs · 2004Review
- Diabetic nephropathy. Its relationship to hypertension and means of pharmacological intervention.Drugs · 1997Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance is generally interpreted as the physiological state under which insulin causes a reduced glucose-lowering effect. Hyperinsulinaemia is considered to be a result of insulin resistance. Many recent studies have suggested that hyperinsulinaemia and/or insulin resistance is associated with an elevated blood pressure, whereas several other studies have found a modest or no association. Many factors (e.g. adiposity, age, ethnic difference) have been suggested to confound the insulin-blood pressure relationship. Insulin is thought to raise blood pressure by a few possible mechanisms (e.g. stimulating sympathetic nervous system activity, enhancing renal tubular sodium reabsorption). On the other hand, insulin has also been reported to possess a vasodilatory property. Neither an insulin infusion within a physiological range nor continuously sustained hyperinsulinaemia in patients with insulinoma are associated with elevated blood pressure. Therefore, the relationship between insulin and blood pressure is still under discussion. Among the antihypertensive drugs, angiotensin converting enzyme (ACE) inhibitors seem to have marginal effects of improving insulin sensitivity, but whether this effect would lead to a better prognosis for diabetic patients remains to be proven. Lipid lowering drugs appear to show no benefit in lowering blood glucose.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.