ArticleMolecular and cellular biology1995
Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 107 citations in OpenAlex.
- Forkhead family transcription factor FoxO and neural differentiation.Neurogenetics · 2012Review
- Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB.Molecular biology of the cell · 2008Article
- Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.Blood · 2006Article
- The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling.The Journal of cell biology · 2004Article
- Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development.PLoS biology · 2003Article
- NF-kappa B signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells.Molecular and cellular biology · 2000Article
- Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways.Molecular and cellular biology · 1998Article
- Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis.Molecular and cellular biology · 1998Article
- Growth factor receptor tyrosine kinases acutely regulate neuronal sodium channels through the src signaling pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Suppression of smooth-muscle alpha-actin expression by platelet-derived growth factor in vascular smooth-muscle cells involves Ras and cytosolic phospholipase A2.The Biochemical journal · 1997Article
- Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src.Molecular and cellular biology · 1997Article
- A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.Molecular biology of the cell · 1997Article
- Activation of mitogen-activated protein kinase and p70S6 kinase is not correlated with cerebellar granule cell survival.The Biochemical journal · 1997Article
- Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals.Molecular and cellular biology · 1997Article
- Mouse disabled (mDab1): a Src binding protein implicated in neuronal development.The EMBO journal · 1997Article
- Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiation.Molecular and cellular biology · 1997Article
- Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.The Journal of cell biology · 1996Article
- The fibroblast growth factor receptor-1 is necessary for the induction of neurite outgrowth in PC12 cells by aFGF.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells.Molecular and cellular biology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
When expressed in PC12 cells, the platelet-derived growth factor beta receptor (beta PDGF-R) mediates cell differentiation. Mutational analysis of the beta PDGF-R indicated that persistent receptor stimulation of the Ras/Raf/mitogen-activated protein (MAP) kinase pathway alone was insufficient to sustain PC12 cell differentiation. PDGF receptor activation of signal pathways involving p60c-src or the persistent regulation of phospholipase C gamma was required for PC12 cell differentiation. beta PDGF-R regulation of phosphatidylinositol 3-kinase, the GTPase-activating protein of Ras, and the tyrosine phosphatase, Syp, was not required for PC12 cell differentiation. In contrast to overexpression of oncoproteins involved in regulating the MAP kinase pathway, growth factor receptor-mediated differentiation of PC12 cells requires the integration of other signals with the Ras/Raf/MAP kinase pathway.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.