ArticleThe Journal of clinical investigation1995
Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 89 citations in OpenAlex.
- Genetic Evidence for a Causal Relationship between Hyperlipidemia and Type 2 Diabetes in Mice.International journal of molecular sciences · 2022Article
- Quantitative trait loci that determine plasma insulin levels in FJournal of genetics · 2018Article
- The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism.Nutrition journal · 2017Article
- Quantitative trait loci that control body weight in DDD/Sgn and C57BL/6J inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Identification of Quantitative Trait Loci That Determine Plasma Total-Cholesterol and Triglyceride Concentrations in DDD/Sgn and C57BL/6J Inbred Mice.Cholesterol · 2017Article
- Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains.BMC genetics · 2015Article
- New quantitative trait loci for carotid atherosclerosis identified in an intercross derived from apolipoprotein E-deficient mouse strains.Physiological genomics · 2013Article
- Article
- Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Genetic analysis of complex traits in the emerging Collaborative Cross.Genome research · 2011Article
- The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol.Journal of lipid research · 2011Article
- A high-resolution association mapping panel for the dissection of complex traits in mice.Genome research · 2010Article
- Differences in DBA/1J and DBA/2J reveal lipid QTL genes.Journal of lipid research · 2008Article
- Article
- Haplotype analysis in multiple crosses to identify a QTL gene.Genome research · 2004Article
- A large-sample QTL study in mice: II. Body composition.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8.Journal of lipid research · 2002Article
- Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.The Journal of clinical investigation · 1998Article
- Srb1 maps to mouse chromosome 5 in a region harboring putative QTLs for plasma lipoprotein levels.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
A genetic cross was constructed from two parental inbred strains of mice, NZB/BINJ and SM/J, which differ markedly in their plasma lipoprotein levels. Plasma lipid and apolipoprotein values were measured in 184 F2 progeny on a normal chow diet and on an atherogenic diet. Genetic markers were typed at 126 loci spanning all chromosomes except the Y. Statistical analysis revealed significant linkage or suggestive linkage of lipoprotein levels with markers on a number of chromosomes. Chromosome 1 markers were linked to levels of total cholesterol (lod 5.9) and high density lipoprotein (HDL) cholesterol (lod 8.1), chromosome 5 markers were linked to levels of total cholesterol (lod 6.7) and HDL cholesterol (lod 5.6), and chromosome 7 markers were linked to levels of total plasma triglycerides (lod 5.1) and free fatty acids (lod 5.6). Plasma apoAII levels were linked to the apoAII gene (lod score 19.6) and were highly correlated with plasma HDL cholesterol levels (r = 0.63, P = 0.0001), indicating that apoAII expression influences HDL cholesterol levels. Molecular studies suggested that structural differences in the apoAII polypeptide of the two strains may contribute to differences in clearance of the protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.