Evidence map›Paper›PMID 758126›Full record

ArticleCirculation1979

Diabetes and cardiovascular risk factors: the Framingham study.

W B Kannel, D L McGee

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Circulation, 1979. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04183868 (Comparative Effects of Empagliflozin Versus Glimepiride After 26-weeks of Treatment Add on Metformin on Myocardial Metabolic Rate of Glucose Estimated Through 18FDG-PET in Patients With Type 2 Diabetes), which is not on this map. Cited by 277 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
277citing papers in PubMed, 8 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04183868 phase4completedstarted 2016, after this paper: background citation

Comparative Effects of Empagliflozin Versus Glimepiride After 26-weeks of Treatment Add on Metformin on Myocardial Metabolic Rate of Glucose Estimated Through 18FDG-PET in Patients With Type 2 Diabetes

Ran2016Enrolled26Registered outcomes10Posted comparisons0ConditionsCardiovascular Risk Factor, Type 2 DiabetesArmsempagliflozin 10 mg, Glimepiride 2 mg
PMID 24929430PMID 24463454PMID 26378978PMID 29496507PMID 30999996PMID 8366922PMID 8883708PMID 9673301PMID 9742976PMID 25271206PMID 23404920PMID 22357182other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

277 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,329 citations in OpenAlex.

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  3. Relationship of fat in the pancreas with cardiovascular disease: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
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  11. On-pump versus off-pump coronary artery bypass graft surgery among patients with type 2 diabetes in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2016
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217 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

W B Kannel
D L McGee
Dean McGee Eye Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of cardiovascular disease was compared in non-diabetics and diabetics in the Framingham cohort. In the first 20 years of the study about 6% of the women and 8% of the men were diagnosed as diabetics. The incidence of cardiovascular disease among diabetic men was twice that among non-diabetic men. Among diabetic women the incidence of cardiovascular disease was three times that among non-diabetic women. Judging from a comparison of standardized coefficients for the regression of incidence of cardiovascular disease on specified risk factors, there is no indication that the relationship of risk factors to the subsequent development of cardiovascular disease is different for diabetics and non-diabetics. This study suggests that the role of diabetes as a cardiovascular risk factor does not derive from an altered ability to contend with known risk factors.

Indexed as

Diabetes ComplicationsAgedAge FactorsCardiovascular DiseasesCholesterolCoronary DiseaseFemaleFollow-Up StudiesHumansHypertensionMaleMassachusettsMiddle AgedRheumatic Heart DiseaseRiskSex FactorsCholesterol

Identifiers

PMID758126
OpenAlexW2085087376

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.