Metformin.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

15 citing papers in PubMed.

1. Phase II study of metformin for reduction of obesity-associated breast cancer risk: a randomized controlled trial protocol.BMC cancer · 2016
   Trial
2. Targeting ABCG1 and SREBP-2 mediated cholesterol homeostasis ameliorates Zika virus-induced ocular pathology.iScience · 2024
   Article
3. Viral Hepatitis, Cholesterol Metabolism, and Cholesterol-Lowering Natural Compounds.International journal of molecular sciences · 2022
   Review
4. Metabolic Phenotypes, Dependencies, and Adaptation in Lung Cancer.Cold Spring Harbor perspectives in medicine · 2021
   Review
5. AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?International journal of molecular sciences · 2020
   Review
6. The Metabolic Heterogeneity and Flexibility of Cancer Stem Cells.Cancers · 2020
   Review
7. Metformin as Host-Directed Therapy for TB Treatment: Scoping Review.Frontiers in microbiology · 2020
   Article
8. The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?Open biology · 2019
   Review
9. Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.Cell reports · 2019
   Article
10. The Role of Host Cholesterol During Flavivirus Infection.Frontiers in cellular and infection microbiology · 2018
    Review
11. Inhibition of oxidative phosphorylation suppresses the development of osimertinib resistance in a preclinical model of EGFR-driven lung adenocarcinoma.Oncotarget · 2016
    Article
12. lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1.Cell cycle (Georgetown, Tex.) · 2016
    Article
13. Targeting LKB1 in cancer - exposing and exploiting vulnerabilities.British journal of cancer · 2015
    Review
14. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin.Cancer cell · 2013
    Article
15. Treatment for childhood type 2 diabetes.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2005
    Review

Corrections and comments

• Comment on
  Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group.1995
• Comment on
  Metabolic effects of metformin in non-insulin-dependent diabetes mellitus.1995

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as