Evidence map›Paper›PMID 7658949›Full record

ArticleMedicine and science in sports and exercise1995

Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise.

J G Regensteiner, J Sippel, E T McFarling, E E Wolfel, W R Hiatt

2 registry-linked trialsAbstract readCorrected and Republished Article
PubMed
In one paragraph

Article in Medicine and science in sports and exercise, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 5 pooled it
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02045290 phase3completedstarted 2014, after this paper: background citation

Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (T1D)--Insulin Clamp Ancillary Study for Assessment of Insulin Resistance

Ran2014Enrolled37Registered outcomes3Posted comparisons0ConditionsType 1 DiabetesArmsMetformin, Placebo
PMID 15855566PMID 19915016PMID 2393555PMID 2404722PMID 2573554PMID 2651185PMID 3113569PMID 3297886PMID 3523245PMID 3556289PMID 3825934PMID 6754515other papers from this trial
Open the trial in the graph
NCT02122666 completednot on this mapstarted 2014, after this paper: background citation

Modulating Physiologic Effects Of Phospholipid Metabolism In Obesity And Diabetes; AIM 4: Composition and Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome

TypeobservationalSponsorWashington University School of MedicineRan2014 to 2024Enrolled27ConditionsMetabolic SyndromeArmsmuscle biopsy
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 5 syntheses or guidelines pooled it, 227 citations in OpenAlex.

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  6. Rosiglitazone improves insulin resistance but does not improve exercise capacity in individuals with impaired glucose tolerance: A randomized clinical study.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

J G RegensteinerDepartment of Medicine, University of Colorado School of Medicine, Denver 80262, USA.
J Sippel
E T McFarling
E E Wolfel
W R Hiatt
University of Colorado Denver · US

Funding

NCRR NIH HHS 5 01 RR00051
6 · The paper itself

Abstract

Persons with non-insulin-dependent diabetes mellitus (NIDDM), in the absence of complications, have a decreased exercise performance compared with nondiabetic subjects. However, degree of impairment and factors associated with reduced exercise performance have not been fully characterized. Maximal exercise performance using a graded treadmill protocol was assessed in 10 sedentary persons with uncomplicated NIDDM (aged 51 +/- 7) and 10 healthy age- and activity-matched controls. Potential correlates of exercise performance measured included fasting and post-exercise glucose concentrations and fasting insulin concentration, hemoglobin A1C, hematocrit, and whole blood viscosity. At maximal exercise, diabetic persons had a 24% lower maximal walking time and 20% lower maximal VO2 than controls (both P < 0.05), while hemodynamic measures did not differ between groups. During graded exercise, at work loads below the maximal one, the relationship between VO2 and work load was significantly lower in persons with NIDDM than controls by an average of 16%. No correlations were found between peak exercise performance and any of the potential correlates of exercise performance measured. We conclude that persons with NIDDM have an impaired peak exercise performance not associated with degree of glycemic control. The reduced rate of increase in oxygen consumption during increasing submaximal work loads in NIDDM suggests that limitations in oxygen delivery may impair exercise performance in otherwise healthy persons with diabetes.

Indexed as

Oxygen ConsumptionAge FactorsBlood ViscosityDiabetes Mellitus, Type 2ExerciseExercise TestFemaleHematocritHumansMaleMatched-Pair AnalysisMiddle AgedSex Factors

Identifiers

PMID7658949
OpenAlexW2036576882

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.