ArticleAmerican journal of human genetics1995
Complete multipoint sib-pair analysis of qualitative and quantitative traits.
Article in American journal of human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 209 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
209 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program.Atherosclerosis · 2014Pooled it
- Genome-wide linkage and regional association study of blood pressure response to the cold pressor test in Han Chinese: the genetic epidemiology network of salt sensitivity study.Circulation. Cardiovascular genetics · 2014Trial
- Genome-wide linkage and positional candidate gene study of blood pressure response to dietary potassium intervention: the genetic epidemiology network of salt sensitivity study.Circulation. Cardiovascular genetics · 2010Trial
- False positive rates in a genomic screen for complex quantitative traits.Genetic epidemiology · 1997Trial
- An Integrated Study of Ramie (Ecology and evolution · 2025Article
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- QTL Mapping for Haploid Inducibility Using Genotyping by Sequencing in Maize.Plants (Basel, Switzerland) · 2022Article
- Depth Image-Based Deep Learning of Grasp Planning for Textureless Planar-Faced Objects in Vision-Guided Robotic Bin-Picking.Sensors (Basel, Switzerland) · 2020Article
- The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights.International journal of molecular sciences · 2019Review
- A Rare Variant Nonparametric Linkage Method for Nuclear and Extended Pedigrees with Application to Late-Onset Alzheimer Disease via WGS Data.American journal of human genetics · 2019Article
- Combining CDKN1A gene expression and genome-wide SNPs in a twin cohort to gain insight into the heritability of individual radiosensitivity.Functional & integrative genomics · 2019Article
- Associations between homocysteine metabolism related SNPs and carotid intima-media thickness: a Chinese sib pair study.Journal of thrombosis and thrombolysis · 2017Article
- Article
- 2015 Curt Stern Award.American journal of human genetics · 2016Article
- Visualization of haplotype sharing patterns in pedigree samples.Human heredity · 2014Article
- A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine.Journal of bone and mineral metabolism · 2013Article
- Twins for epigenetic studies of human aging and development.Ageing research reviews · 2013Review
- A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- Integration of SNP genotyping confidence scores in IBD inference.Bioinformatics (Oxford, England) · 2011Article
- Linkage analysis in the next-generation sequencing era.Human heredity · 2011Review
149 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sib-pair analysis is an increasingly important tool for genetic dissection of complex traits. Current methods for sib-pair analysis are primarily based on studying individual genetic markers one at a time and thus fail to use the full inheritance information provided by multipoint linkage analysis. In this paper, we describe how to extract the complete multipoint inheritance information for each sib pair. We then describe methods that use this information to map loci affecting traits, thereby providing a unified approach to both qualitative and quantitative traits. Specifically, complete multipoint approaches are presented for (1) exclusion mapping of qualitative traits; (2) maximum-likelihood mapping of qualitative traits; (3) information-content mapping, showing the extent to which all inheritance information has been extracted at each location in the genome; and (4) quantitative-trait mapping, by two parametric methods and one nonparametric method. In addition, we explore the effects of marker density, marker polymorphism, and availability of parents on the information content of a study. We have implemented the analysis methods in a new computer package, MAPMAKER/SIBS. With this computer package, complete multipoint analysis with dozens of markers in hundreds of sib pairs can be carried out in minutes.
Indexed as
Identifiers
7668271PMC1801561What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.