ReviewEuropean journal of pediatrics1995
The role of polyols in the pathophysiology of hypergalactosemia.
Review in European journal of pediatrics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 65 citations in OpenAlex.
- Harnessing the Power of Purple Sweet Potato Color andInternational journal of molecular sciences · 2022Article
- Galactosemia: Biochemistry, Molecular Genetics, Newborn Screening, and Treatment.Biomolecules · 2022Review
- Physiological and Pathological Roles of Aldose Reductase.Metabolites · 2021Review
- Novel mRNA-Based Therapy Reduces Toxic Galactose Metabolites and Overcomes Galactose Sensitivity in a Mouse Model of Classic Galactosemia.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- Sweet and sour: an update on classic galactosemia.Journal of inherited metabolic disease · 2017Review
- The male reproductive system in classic galactosemia: cryptorchidism and low semen volume.Journal of inherited metabolic disease · 2013Article
- Is prenatal myo-inositol deficiency a mechanism of CNS injury in galactosemia?Journal of inherited metabolic disease · 2011Review
- Galactose toxicity in animals.IUBMB life · 2009Review
- Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression.Journal of the neurological sciences · 2008Article
- ARHI: A new target of galactose toxicity in Classic Galactosemia.Bioscience hypotheses · 2008Article
- Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy.American journal of human genetics · 2004Article
- Komrower Lecture. Galactosaemia today: the enigma and the challenge.Journal of inherited metabolic disease · 1998Article
- Importance of sustained high glucose condition in the development of diabetic osteopenia: possible involvement of the polyol pathway.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1997Article
- Galactosaemia: pathogenesis and treatment.Journal of inherited metabolic disease · 1996Review
- Galactitol in galactosemia.European journal of pediatrics · 1995Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular accumulation of galactitol has been suggested to cause the apparent dietary-independent, long-term complications in classic galactosemia. Experimental animals rendered hypergalactosemic by galactose feeding accumulate tissue galactitol, as well as millimolar quantities of galactose, and manifest biochemical, physiological and pathological abnormalities which are generally eliminated or curtailed by the concomitant administration of an aldose reductase inhibitor. This includes reduced cellular content of the cyclic polyol, myo-inositol, which like galactitol may function as an alternate intracellular osmolyte. However, the abnormalities detected in experimental galactosemic animals are more compatible with findings in experimental diabetes mellitus than in human galactosemia. Because patients with galactokinase deficiency fail to manifest the CNS and ovarian complications which characterize classic galactosemia, yet during long-term lactose restriction excrete comparable urinary quantities of galactitol, this polyol alone is not likely to play an important role during postnatal life in the pathogenesis of long-term complications. Notwithstanding, a role for either galactitol or myo-inositol in an intrauterine toxicity cannot be dismissed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.