ArticleMedicine and science in sports and exercise1995
Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise.
Article in Medicine and science in sports and exercise, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise Intolerance in Type 2 Diabetes: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2025Pooled it
- Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes.Diabetes · 2018Trial
- Descriptive epidemiology of muscle-strengthening activities in Japanese middle-aged and older adults: the Hisayama Study.BMJ public health · 2024Article
- Celecoxib ameliorates diabetic sarcopenia by inhibiting inflammation, stress response, mitochondrial dysfunction, and subsequent activation of the protein degradation systems.Frontiers in pharmacology · 2024Article
- Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes.The Journal of physiology · 2022Article
- Correlates of cardiorespiratory fitness among overweight or obese individuals with type 2 diabetes.BMJ open diabetes research & care · 2022Article
- Mechanistic Causes of Reduced Cardiorespiratory Fitness in Type 2 Diabetes.Journal of the Endocrine Society · 2020Review
- Muscle metabolic reprogramming underlies the resistance of liver fatty acid-binding protein (LFABP)-null mice to high-fat feeding-induced decline in exercise capacity.The Journal of biological chemistry · 2019Article
- Exercise capacity in diabetes mellitus is predicted by activity status and cardiac size rather than cardiac function: a case control study.Cardiovascular diabetology · 2018Article
- Identifying the Critical Gaps in Research on Sex Differences in Metabolism Across the Life Span.Endocrinology · 2018Review
- Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes.Cardiovascular diabetology · 2017Article
- Impact of type 2 diabetes on cardiorespiratory function and exercise performance.Physiological reports · 2017Article
- Sex differences in the effects of type 2 diabetes on exercise performance.Medicine and science in sports and exercise · 2015Article
- Cardiovascular control during exercise in type 2 diabetes mellitus.Journal of diabetes research · 2015Review
- Targeting mitochondria to restore failed adaptation to exercise in diabetes.Biochemical Society transactions · 2014Review
- Type 2 diabetes mellitus and exercise impairment.Reviews in endocrine & metabolic disorders · 2013Review
- What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review.Diabetologia · 2012Review
- Alterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoa.Clinical and translational science · 2012Article
- Oxidative stress in cardiac and skeletal muscle dysfunction associated with diabetes mellitus.Journal of clinical biochemistry and nutrition · 2011Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Persons with non-insulin-dependent diabetes mellitus (NIDDM), in the absence of complications, have a decreased exercise performance compared with nondiabetic subjects. However, degree of impairment and factors associated with reduced exercise performance have not been fully characterized. Maximal exercise performance using a graded treadmill protocol was assessed in 10 sedentary persons with uncomplicated NIDDM (aged 51 +/- 7) and 10 healthy age- and activity-matched controls. Potential correlates of exercise performance measured included fasting and post-exercise glucose concentrations and fasting insulin concentration, hemoglobin A1C, hematocrit, and whole blood viscosity. At maximal exercise, diabetic persons had a 24% lower maximal walking time and 20% lower maximal VO2 than controls (both P < 0.05), while hemodynamic measures did not differ between groups. During graded exercise, at work loads below the maximal one, the relationship between VO2 and work load was significantly lower in persons with NIDDM than controls by an average of 16%. No correlations were found between peak exercise performance and any of the potential correlates of exercise performance measured. We conclude that persons with NIDDM have an impaired peak exercise performance not associated with degree of glycemic control. The reduced rate of increase in oxygen consumption during increasing submaximal work loads in NIDDM suggests that limitations in oxygen delivery may impair exercise performance in otherwise healthy persons with diabetes.
Indexed as
Identifiers
7674869What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.