ArticleHuman genetics1995
An apolipoprotein CIII marker associated with hypertriglyceridemia in Caucasians also confers increased risk in a west Japanese population.
Article in Human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 62 citations in OpenAlex.
- Efficacy and safety of olezarsen in lowering apolipoprotein C-III and triglycerides in healthy Japanese Americans.Lipids in health and disease · 2024Trial
- Association of serum lipids and coronary artery disease with polymorphisms in the apolipoprotein AI-CIII-AIV gene cluster.Cogent medicine · 2016Article
- Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout.Rheumatology (Oxford, England) · 2016Article
- Apolipoprotein Gene Polymorphisms (APOB, APOC111, APOE) in the Development of Coronary Heart Disease in Ethnic Groups of Kazakhstan.Journal of genetic syndromes & gene therapy · 2014Article
- SstI Polymorphism of the Apolipoprotein CIII Gene in Iranian Hyperlipidemic Patients: A Study in Semnan Province.Iranian journal of basic medical sciences · 2011Article
- Influence of genetic variants in the apolipoprotein A5 and C3 gene on lipids, lipoproteins, and its association with coronary artery disease in Indians.Journal of community genetics · 2010Article
- Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms.Atherosclerosis · 2008Article
- Article
- Apolipoprotein C3 SstI polymorphism in the risk assessment of CAD.Molecular and cellular biochemistry · 2004Article
- Population prevalence of APOE, APOC3 and PPAR-alpha mutations associated to hypertriglyceridemia in French Canadians.Journal of human genetics · 2004Article
- Study of apolipoproteinc3 Sstl polymorphism in healthy volunteers from Northern India.Indian journal of clinical biochemistry : IJCB · 2003Article
- The apolipoprotein CIII T2854G variants are associated with postprandial triacylglycerol concentrations in normolipidemic Korean men.Journal of human genetics · 2003Article
- Article
- A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans.American journal of human genetics · 2000Article
- Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins.American journal of human genetics · 1998Article
- Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.The Journal of clinical investigation · 1995Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Polymorphisms and haplotypes at the adjacent apolipoprotein (apo) AI and CIII gene loci were investigated in 61 Japanese patients with triglycerides greater than 350 mg/dl and in 66 unrelated normolipidemic subjects. The polymorphic sites were the SstI site in the apoCIII 3' untranslated region, whose presence has previously been shown to be associated with hypertriglyceridemia (HTG) in Caucasians, and the MspI site in the third intron of the apoAI gene. The frequencies of the SstI minor allele (S2) were 0.48 in HTG patients and 0.25 in normolipidemic subjects (P < 0.00015). The frequencies of the MspI minor allele (M2) were 0.61 in HTG patients and 0.33 in normolipidemic subjects (P < 0.00001). The two polymorphic sites were in strong linkage disequilibrium, and maximum likelihood analysis supported the existence of three of the four possible haplotypes: S1-M1, S1-M2, and S2-M2. Since all S2 alleles were estimated to be present on M2-bearing chromosomes, the HTG-associated S2-M2 haplotype conferred the same approximate relative risk as the S2 allele alone when compared with the other two haplotypes (odds ratio 2.8). This study demonstrates that the S2 allele is a marker for HTG among west Japanese subjects as well as among Caucasians. The results suggest that S2-M2 chromosomes carry HTG susceptibility sequences that predate the separation of the Asian and Caucasian races.
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