Evidence map›Paper›PMID 7776501›Full record

Trial reportJAMA1995

Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis.

H N Hodis, W J Mack, L LaBree, L Cashin-Hemphill, A Sevanian, R Johnson, S P Azen

2 registry-linked trialsAbstract readClinical TrialRandomized Controlled Trial
PubMed
In one paragraph

Trial report in JAMA, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00000599. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000599 phase3completed

Cholesterol-Lowering Atherosclerosis Study (CLAS)

Ran1980Registered outcomes0Posted comparisons0ConditionsArterial Occlusive Diseases, Atherosclerosis, Cardiovascular Diseases, Carotid Artery DiseasesArmscolestipol, diet, fat-restricted, niacin
PMID 8921775PMID 8616937PMID 8319334PMID 1547194PMID 1951831PMID 1991366PMID 1998656PMID 2243429PMID 3295315PMID 3327654PMID 8248954PMID 1451241other papers from this trial
Open the trial in the graph
NCT00005696 completednot on this map

Early Atherosclerosis Change in Two Clinical Trials

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran1994 to 1996ConditionsCardiovascular Diseases, Heart Diseases, Carotid Artery Diseases, Coronary Disease
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 325 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Vitamin E: Where Are We Now in Vascular Diseases?Life (Basel, Switzerland) · 2022
    Review
  8. Article
  9. Lycopene and kidney; future potential application.Journal of nephropharmacology · 2015
    Article
  10. Article
  11. Analysis of circulating lipid-phase micronutrients in humans by HPLC: review and overview of new developments.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2013
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Observational versus experimental studies: what's the evidence for a hierarchy?NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2004
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

H N HodisAtherosclerosis Research Unit, University of Southern California School of Medicine, Los Angeles 90033, USA.
W J Mack
L LaBree
L Cashin-Hemphill
A Sevanian
R Johnson
S P Azen
University of Southern California · US

Funding

THREE VESSEL RISK FACTOR ANALYSIS COMPLETION OF CLASR01HL045005 · UNIVERSITY OF SOUTHERN CALIFORNIA · 1991 to 1993
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EARLY ATHEROSCLEROSIS CHANGE IN TWO CLINICAL TRIALSR01HL049885 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1994 to 1995
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NHLBI NIH HHS R01-HL-45005NHLBI NIH HHS R01-HL-49885
6 · The paper itself

Abstract

objectiveTo explore the association of supplementary and dietary vitamin E and C intake with the progression of coronary artery disease.

designA subgroup analysis of the on-trial antioxidant vitamin intake database acquired in the Cholesterol Lowering Atherosclerosis Study, a randomized, placebo-controlled, serial angiographic clinical trial evaluating the risk and benefit of colestipol-niacin on coronary artery disease progression.

settingCommunity- and university-based cardiac catheterization laboratories. SUBJECTS: A total of 156 men aged 40 to 59 years with previous coronary artery bypass graft surgery.

interventionSupplementary and dietary vitamin E and C intake (nonrandomized) in association with cholesterol-lowering diet and either colestipol-niacin or placebo (randomized). OUTCOME: Change per subject in the percentage of vessel diameter obstructed because of stenosis (%S) determined by quantitative coronary angiography after 2 years of randomized therapy on all lesions, mild/moderate lesions (< 50%S), and severe lesions (> or = 50%S).

resultsOverall, subjects with supplementary vitamin E intake of 100 IU per day or greater demonstrated less coronary artery lesion progression than did subjects with supplementary vitamin E intake less than 100 IU per day for all lesions (P = .04) and for mild/moderate lesions (P = .01). Within the drug group, benefit of supplementary vitamin E intake was found for all lesions (P = .02) and mild/moderate lesions (P = .01). Within the placebo group, benefit of supplementary vitamin E intake was not found. No benefit was found for use of supplementary vitamin C exclusively or in conjunction with supplementary vitamin E, use of multivitamins, or increased dietary intake of vitamin E or vitamin C.

conclusionsThese results indicate an association between supplementary vitamin E intake and angiographically demonstrated reduction in coronary artery lesion progression. Verification from carefully designed, randomized, serial arterial imaging end point trials is needed.

Indexed as

AdultAnalysis of VarianceAntioxidantsAscorbic AcidColestipolCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseDiet, AtherogenicFood, FortifiedHumansMaleMiddle AgedRandomized Controlled Trials as TopicVitamin EAntioxidantsAscorbic AcidColestipolVitamin E

Identifiers

PMID7776501
OpenAlexW2043948984

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.