ArticleMolecular and cellular biology1994
Participation of Ets transcription factors in the glucocorticoid response of the rat tyrosine aminotransferase gene.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Hepatic Glucocorticoid Receptor Action and Glucose Homeostasis.Endocrine reviews · 2026Review
- Transcriptional regulation of FoxO3 gene by glucocorticoids in murine myotubes.American journal of physiology. Endocrinology and metabolism · 2016Article
- Transcriptional regulation of human dual specificity protein phosphatase 1 (DUSP1) gene by glucocorticoids.PloS one · 2010Article
- Erk signaling and chromatin remodeling in MMTV promoter activation by progestins.Nuclear receptor signaling · 2009Review
- Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation.Genes & development · 2002Article
- A distal region, hypersensitive to DNase I, plays a key role in regulating rabbit whey acidic protein gene expression.The Biochemical journal · 2001Article
- Glucocorticoid-induced DNA demethylation and gene memory during development.The EMBO journal · 2001Article
- Synergistic action of GA-binding protein and glucocorticoid receptor in transcription from the mouse mammary tumor virus promoter.Journal of virology · 2000Article
- Role of the Ets-1 transcription factor during activation of rat hepatic stellate cells in culture.The American journal of pathology · 1999Article
- Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene.Molecular and cellular biology · 1998Article
- Glucocorticoids are insufficient for neonatal gene induction in the liver.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions.Molecular and cellular biology · 1998Article
- In vivo characterization of transcriptional regulatory sequences involved in the defence-associated expression of the tobacco retrotransposon Tnt1.Plant molecular biology · 1997Article
- Regulation of tyrosine aminotransferase gene expression by glucocorticoids in quiescent and regenerating liver.The Biochemical journal · 1996Article
- A compilation of composite regulatory elements affecting gene transcription in vertebrates.Nucleic acids research · 1995Article
- Glucocorticoids and protein kinase A coordinately modulate transcription factor recruitment at a glucocorticoid-responsive unit.Molecular and cellular biology · 1995Article
- Tissue specificity of a glucocorticoid-dependent enhancer in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- The nonconserved hinge region and distinct amino-terminal domains of the ROR alpha orphan nuclear receptor isoforms are required for proper DNA bending and ROR alpha-DNA interactions.Molecular and cellular biology · 1995Article
- Developmental control of transcription of a retina-specific gene, QR1, during differentiation: involvement of factors from the POU family.Molecular and cellular biology · 1995Article
- Development of computational methods to search for FoxA transcription factor binding sites, their experimental verification and application to the analysis of ChIP-seq data.Doklady. Biochemistry and biophysicsArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that two remote glucocorticoid-responsive units (GRUs) of the rat tyrosine aminotransferase (TAT) gene contain multiple binding sites for several transcription factor families, including the glucocorticoid receptor (GR). We report here the identification of two novel binding sites for members of the Ets family of transcription factors in one of these GRUs. One of these binding sites overlaps the major GR-binding site (GRBS), whereas the other is located in its vicinity. Inactivation of the latter binding site leads to a twofold reduction of the glucocorticoid response, whereas inactivation of the site overlapping the GRBS has no detectable effect. In vivo footprinting analysis reveals that the active site is occupied in a glucocorticoid-independent manner, in a TAT-expressing cell line, even though it is located at a position where there is a glucocorticoid-dependent alteration of the nucleosomal structure. This same site is not occupied in a cell line that does not express TAT but expresses Ets-related DNA-binding activities, suggesting the existence of an inhibitory effect of chromatin structure at a hierarchical level above the nucleosome. The inactive Ets-binding site that overlaps the GRBS is not occupied even in TAT-expressing cells. However, this same overlapping site can confer Ets-dependent stimulation of both basal and glucocorticoid-induced levels when it is isolated from the GRU and duplicated. Ets-1 expression in COS cells mimics the activity of the Ets-related activities present in hepatoma cells. These Ets-binding sites could participate in the integration of the glucocorticoid response of the TAT gene with signal transduction pathways triggered by other nonsteroidal extracellular stimuli.
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