ReviewMolecular biology reports1994
Translation and the cytoskeleton: a mechanism for targeted protein synthesis.
Review in Molecular biology reports, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 93 citations in OpenAlex.
- A kinesin adapter directly mediates dendritic mRNA localization during neural development in mice.The Journal of biological chemistry · 2020Article
- Triiodothyronine differentially modulates the LH and FSH synthesis and secretion in male rats.Endocrine · 2018Article
- Actin and endocytosis in budding yeast.Genetics · 2015Review
- Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins.Cell · 2012Article
- Histone deacetylase 6 associates with ribosomes and regulates de novo protein translation during arsenite stress.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Interactions between laminin receptor and the cytoskeleton during translation and cell motility.PloS one · 2011Article
- Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.BMC cell biology · 2010Article
- Micropatterning of single endothelial cell shape reveals a tight coupling between nuclear volume in G1 and proliferation.Biophysical journal · 2008Article
- Elongation factor 1alpha binds to the region of the metallothionein-1 mRNA implicated in perinuclear localization--importance of an internal stem-loop.RNA (New York, N.Y.) · 2006Article
- Rapid depletion of mutant eukaryotic initiation factor 5A at restrictive temperature reveals connections to actin cytoskeleton and cell cycle progression.Molecular genetics and genomics : MGG · 2006Article
- An eleven nucleotide section of the 3'-untranslated region is required for perinuclear localization of rat metallothionein-1 mRNA.The Biochemical journal · 2005Article
- The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2.Molecular biology of the cell · 2005Article
- Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library.Molecular and cellular biochemistry · 2004Article
- eEF1A isoforms change in abundance and actin-binding activity during maize endosperm development.Plant physiology · 2003Article
- Dual regulated RNA transport pathways to the cortical region in developing rice endosperm.The Plant cell · 2003Article
- Article
- The 3' untranslated region of human vimentin mRNA interacts with protein complexes containing eEF-1gamma and HAX-1.Nucleic acids research · 2002Article
- Retroviral RNA elements integrate components of post-transcriptional gene expression.Life sciences · 2001Review
- Messenger RNA-binding properties of nonpolysomal ribonucleoproteins from heat-stressed tomato cellsPlant physiology · 1999Article
- Actin depolymerization affects stress-induced translational activity of potato tuber tissuePlant physiology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review describes the critical evidence that in eukaryotic cells polyribosomes, mRNAs and components of the protein synthetic machinery are associated with the cytoskeleton. The role of microtubules, intermediate filaments and microfilaments are discussed; at present most evidence suggests that polyribosomes interact with the actin filaments. The use of non-ionic detergent/deoxycholate treatment in the isolation of cytoskeletal-bound polysomes is described and the conclusion reached that at low salt concentrations this leads to mixed preparations of polysomes derived from both the cytoskeleton and the endoplasmic reticulum. At present the best approach for isolation of cytoskeletal-bound polysomes appears to involve extraction with salt concentrations greater than 130 mM after an initial non-ionic detergent treatment. Such polysomes appear to be enriched in certain mRNAs and thus it is suggested that they are involved in translation of a unique set of proteins. The evidence for mRNA localisation is presented and the role of the cytoskeleton in transport and localisation of RNA discussed. Recent data on the role of the 3' untranslated region in the targeting of mRNAs both to particular regions of the cell and for translation on cytoskeletal-bound polysomes is described. The hypothesis is developed that the association of polysomes with the cytoskeleton is the basis of a mechanism for the targeting of mRNAs and the compartmentalization of protein synthesis.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.