ArticleMolecular and cellular biology1994
YY1 represses rat serum amyloid A1 gene transcription and is antagonized by NF-kappa B during acute-phase response.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 114 citations in OpenAlex.
- Interaction between endogenous microRNAs and virus-derived small RNAs controls viral replication in insect vectors.PLoS pathogens · 2022Article
- Serum amyloid a, a potential biomarker both in serum and tissue, correlates with ovarian cancer progression.Journal of ovarian research · 2020Article
- RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme.Oncogenesis · 2019Article
- miR‑29a suppresses IL‑13‑induced cell invasion by inhibiting YY1 in the AKT pathway in lung adenocarcinoma A549 cells.Oncology reports · 2018Article
- Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis.Nucleic acids research · 2017Article
- Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis.Oncotarget · 2016Article
- Transcriptome profiling of the cancer and adjacent nontumor tissues from cervical squamous cell carcinoma patients by RNA sequencing.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Characterization of rat serum amyloid A4 (SAA4): a novel member of the SAA superfamily.Biochemical and biophysical research communications · 2014Article
- Expression of serum amyloid A in uterine cervical cancer.Diagnostic pathology · 2014Article
- Biphasic recruitment of transcriptional repressors to the murine cytomegalovirus major immediate-early promoter during the course of infection in vivo.Journal of virology · 2010Article
- Yin yang 1 regulates the expression of snail through a distal enhancer.Molecular cancer research : MCR · 2009Article
- YY1 repressing peroxisome proliferator-activated receptor delta promoter.Molecular and cellular biochemistry · 2008Article
- Genes invoked in the ovarian transition to menopause.Nucleic acids research · 2006Article
- Transcription factor YY1 functions as a PcG protein in vivo.The EMBO journal · 2003Article
- Role of the E1A Rb-binding domain in repression of the NF-kappa B-dependent defense against tumor necrosis factor-alpha.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Regulation of serum amyloid A protein expression during the acute-phase response.The Biochemical journal · 1998Review
- Role of the transcription start site core region and transcription factor YY1 in Rous sarcoma virus long terminal repeat promoter activity.Journal of virology · 1998Article
- NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa.Molecular and cellular biology · 1998Article
- DNA-binding protein Pur alpha and transcription factor YY1 function as transcription activators of the neuron-specific FE65 gene promoter.The Biochemical journal · 1997Article
- C/EBP factor suppression of inhibition of type II secreted phospholipase A2 promoter in HepG2 cells: possible role of single-strand binding proteins.Molecular and cellular biology · 1997Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Serum amyloid A (SAA), one of the major acute-phase proteins, increases several hundredfold in concentration in plasma following acute inflammation, primarily as a result of a 200-fold increase in its transcriptional rate. Functional analysis of the rat SAA1 promoter has identified a 65-bp cytokine response unit (CRU; positions -135 to -71) that could confer cytokine responsiveness on a heterologous promoter. Within this CRU, two cis-regulatory elements, corresponding to NF-kappa B- and C/EBP-binding sites, were found to be functionally important and exerted synergistic effects on induced SAA1 expression. In this report, we show that a third transcription factor interacts with the CRU through a region located between the NF-kappa B- and C/EBP-binding sites. On the basis of its gel mobility shift patterns, ubiquitous binding activity, sequence specificity of DNA binding, zinc-dependent binding activity, and gel mobility supershift by specific antibodies, we concluded that this factor is identical to YY1. Methylation interference studies revealed that YY1 binding sequences overlapped with those of NF-kappa B, and gel mobility studies showed that NF-kappa binding to the CRU was effectively inhibited by YY1. Consistent with its presumed antagonistic role to NF-kappa B, YY1 exerted a negative effect on SAA1 expression, whereas disruption of its binding in the promoter elevated basal and cytokine-induced activities. Furthermore, overexpression of YY1 trans-repressed SAA1 promoter activity. Thus, our results demonstrate that SAA1 expression is tightly regulated by an on-off switch of activators and repressors, presumably to ensure that it is expressed only under appropriate physiological conditions.
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