ArticleJournal of epidemiology and community health1993
Physical activity and risk of peripheral arterial disease in the general population: Edinburgh Artery Study.
Article in Journal of epidemiology and community health, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 82 citations in OpenAlex.
- The effect of exercise training on ankle-brachial index in type 2 diabetes.Atherosclerosis · 2013Trial
- Association between cardiorespiratory fitness and impaired vascular function in type 2 diabetes.World journal of diabetes · 2025Article
- Causal Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Peripheral Artery Disease: A Mendelian Randomization Approach.Journal of the American Heart Association · 2022Article
- Review
- Dose-Response Relationship Between Physical Activity and the Incidence of Peripheral Artery Disease in General Population: Insights From the National Health and Nutrition Examination Survey 1999-2004.Frontiers in cardiovascular medicine · 2021Article
- Physical Activity and Subsequent Risk of Hospitalization With Peripheral Artery Disease and Critical Limb Ischemia in the ARIC Study.Journal of the American Heart Association · 2019Article
- The effect of motivational interviewing-based intervention using self-determination theory on promotion of physical activity among women in reproductive age: A randomized clinical trial.Electronic physician · 2017Article
- Peripheral artery disease: epidemiology and global perspectives.Nature reviews. Cardiology · 2017Review
- Objectively measured physical activity and sedentary behaviour and ankle brachial index: Cross-sectional and longitudinal associations in older men.Atherosclerosis · 2016Article
- Association between physical activity and peripheral artery disease and carotid artery stenosis in a self-referred population of 3 million adults.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Physical activity, sex, and socioeconomic status: A population based study.ARYA atherosclerosis · 2013Article
- Low lifetime recreational activity is a risk factor for peripheral arterial disease.Journal of vascular surgery · 2011Article
- Peripheral Arterial Disease study (PERART): prevalence and predictive values of asymptomatic peripheral arterial occlusive disease related to cardiovascular morbidity and mortality.BMC public health · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectiveTo determine associations between physical activity at age 35-45 years with peripheral arterial disease and cardiovascular risk factors at age 55-74 years.
designCross sectional survey of the general population--Edinburgh Artery Study. The presence of peripheral arterial disease was determined using the WHO/Rose questionnaire on intermittent claudication, and the ankle brachial pressure index at rest and during reactive hyperaemia. Levels of physical activity undertaken at the time of the survey and at the times the subjects were aged 35-45 years were measured by self administered recall questionnaire.
settingCity of Edinburgh, Scotland.
participantsAltogether 1592 men and women aged 55 to 74 years, selected from the age-sex registers of 10 general practices spread geographically and socioeconomically throughout the city. MAIN
resultsParticipation in moderate or strenuous activity when aged 35-45 years was reported by 66% of men and 40% of women. In men, but not in women, less peripheral arterial disease (measured by an increasing trend in the ankle brachial pressure index) was found with increasing amounts of exercise at age 35-45 years (p < 0.001). Higher levels of exercise at age 35-45 years were associated with lower blood viscosity (p < 0.05) and plasma fibrinogen levels (p < 0.05) in men and women aged 55-74 years, and also with higher current alcohol intake (p < 0.001) and high density lipoprotein cholesterol concentrations (p < 0.01) in women aged 55-74 years. After adjustment for age, sex, life-time smoking, social class, body mass index, and alcohol intake, the association between leisure activity aged 35-45 years and the ankle brachial pressure index aged 55-74 years remained highly significant in men who had at some time smoked (p < 0.001) but not in men or women who had never smoked (p > 0.05).
conclusionThe risk of peripheral arterial disease, particularly among male smokers, is inversely related to previous physical activity in early middle age, suggesting a protective effect of exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.