ArticleThe Journal of clinical investigation1994
Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 114 citations in OpenAlex.
- A systems and computational biology perspective on advancing CAR therapy.Seminars in cancer biology · 2023Review
- A tale of two proteins: PACT and PKR and their roles in inflammation.The FEBS journal · 2021Review
- Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network.Development (Cambridge, England) · 2017Article
- Targeting polo-like kinase 1 suppresses essential functions of alloreactive T cells.Immunologic research · 2016Article
- Lenalidomide enhances antitumor functions of chimeric antigen receptor modified T cells.Oncoimmunology · 2016Article
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- The C-type lectin OCILRP2 costimulates EL4 T cell activation via the DAP12-Raf-MAP kinase pathway.PloS one · 2014Article
- BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway.British journal of pharmacology · 2013Article
- Decreased diacylglycerol metabolism enhances ERK activation and augments CD8+ T cell functional responses.The Journal of biological chemistry · 2011Article
- All-trans-retinoic acid and Erk1/2 signaling synergistically regulate the expression of CD300B in human monocytic cells.Cellular immunology · 2011Article
- Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells.BMC immunology · 2010Article
- Divergent effects of norepinephrine, dopamine and substance P on the activation, differentiation and effector functions of human cytotoxic T lymphocytes.BMC immunology · 2009Article
- T-cell receptor signaling is mediated by transient Lck activity, which is inhibited by inorganic mercury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Article
- Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6.The Journal of infectious diseases · 2009Article
- Protein-bound polysaccharide K augments IL-2 production from murine mesenteric lymph node CD4+ T cells by modulating T cell receptor signaling.Cancer immunology, immunotherapy : CII · 2008Article
- p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells.The Journal of biological chemistry · 2008Article
- GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling.The Journal of clinical investigation · 2007Article
- Inhibition of lymphocyte activation and function by the prenylation inhibitor L-778,123.Investigational new drugs · 2005Article
- Activation of CD4 T cells by Raf-independent effectors of Ras.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Stimulation of T cells with antibodies directed towards the T cell receptor complex results in the activation of mitogen-associated protein kinase (MAPK). Two pathways have been described in other cell types that can lead to MAPK activation. One of these pathways involves the activation of Ras, leading to the activation of Raf-1, and the subsequent activation of MEK (MAPK or ERK kinase). The contribution of this pathway in T cells for anti-CD3 or phorbol myristate acetate (PMA)-mediated MAPK activation was examined. We detected the kinase activities of Raf-1 and MEK towards their substrates (MEK for Raf-1 and MAPK for MEK) in this pathway leading to the activation of MAPK. Stimulation of the T cells with either anti-CD3 antibody or PMA resulted in a rapid activation of both Ras and Raf-1. MEK activity towards kinase-active or -inactive recombinant MAPK also increased upon stimulation. In addition, both MAPK and p90rsk were activated in these cells. We suggest that activation of MAPK and the subsequent activation of ribosomal S6 kinase (p90rsk) occurs by the Ras/Raf-1/MEK cascade in T lymphocytes stimulated by ligation of the T cell receptor complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.