ArticleAmerican journal of human genetics1994
Computation of identity-by-descent proportions shared by two siblings.
Article in American journal of human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Estimating the timing of multiple admixture events using 3-locus linkage disequilibrium.PLoS genetics · 2022Article
- The lengths of admixture tracts.Genetics · 2014Article
- Review
- Article
- Modeling of identity-by-descent processes along a chromosome between haplotypes and their genotyped ancestors.Genetics · 2011Article
- Article
- Whole genome approaches to quantitative genetics.Genetica · 2009Review
- Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings.PLoS genetics · 2006Article
- Distribution of genome shared identical by descent by two individuals in grandparent-type relationship.Genetics · 2000Article
- The probability distribution of the amount of an individual's genome surviving to the following generation.Genetics · 1996Article
- Complete multipoint sib-pair analysis of qualitative and quantitative traits.American journal of human genetics · 1995Article
- Proportion of genome shared identical by descent by relatives: concept, computation, and applications.American journal of human genetics · 1995Article
- Proportion of genes survived in offspring conditional on inheritance of flanking markers.Genetics · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
I provide a novel approach to computing the mean and variance of the proportion of genetic material shared identical by descent (IBD) by sibling pairs in a specified chromosomal region, conditional on observed marker data. I first show that each chromosome in an offspring can be represented by a two-state Markov chain, with the time parameter being the map distance along the chromosome. On this basis, I show that IBD proportion can be written as a stochastic integral and that the computation of its mean and variance can be reduced to evaluation of an integral of some elementary functions. In addition, I show how Goldgar's model can be extended to include dominance effects. Several examples are provided to illustrate the calculation.
Indexed as
Identifiers
8198133PMC1918183What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.