ReviewCurrent genetics1993
MCB elements and the regulation of DNA replication genes in yeast.
Review in Current genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity.PLoS pathogens · 2020Article
- The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Yeast gene CMR1/YDL156W is consistently co-expressed with genes participating in DNA-metabolic processes in a variety of stringent clustering experiments.Journal of the Royal Society, Interface · 2013Article
- Conservation and evolution of cis-regulatory systems in ascomycete fungi.PLoS biology · 2004Article
- Article
- Schizosaccharomyces pombe pfh1+ encodes an essential 5' to 3' DNA helicase that is a member of the PIF1 subfamily of DNA helicases.Molecular biology of the cell · 2002Article
- Assessing clusters and motifs from gene expression data.Genome research · 2001Article
- The cohesin complex: sequence homologies, interaction networks and shared motifs.Genome biology · 2001Article
- Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Candidate regulatory sequence elements for cell cycle-dependent transcription in Saccharomyces cerevisiae.Genome research · 1999Article
- DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Xbp1, a stress-induced transcriptional repressor of the Saccharomyces cerevisiae Swi4/Mbp1 family.Molecular and cellular biology · 1997Article
- A computational genomics approach to the identification of gene networks.Nucleic acids research · 1997Article
- Cell cycle regulation of RPA1 transcript levels in the trypanosomatid Crithidia fasciculata.Nucleic acids research · 1997Article
- Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitro.Molecular and cellular biology · 1997Article
- Article
- Transcription of mutS and mutL-homologous genes in Saccharomyces cerevisiae during the cell cycle.Molecular & general genetics : MGG · 1996Article
- Cloning and characterization of RAD17, a gene controlling cell cycle responses to DNA damage in Saccharomyces cerevisiae.Nucleic acids research · 1996Article
- Overexpression of the RNR1 gene rescues Saccharomyces cerevisiae mutants in the mitochondrial DNA polymerase-encoding MIP1 gene.Molecular & general genetics : MGG · 1995Article
- Mutations in RAD27 define a potential link between G1 cyclins and DNA replication.Molecular and cellular biology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotic organisms, genes involved in DNA replication are often subject to some form of cell cycle control. In the yeast Saccharomyces cerevisiae, most of the DNA replication genes that have been characterized to date are regulated at the transcriptional level during G1 to S phase transition. A cis-acting element termed the MluI cell cycle box (or MCB) conveys this pattern of regulation and is common among more than 20 genes involved in DNA synthesis and repair. Recent findings indicate that the MCB element is well conserved among fungi and may play a role in controlling entry into the cell division cycle. It is evident from studies in higher systems, however, that transcriptional regulation is not the only form of control that governs the cell-cycle-dependent expression of DNA replication genes. Moreover, it is unclear why this general pattern of regulation exists for so many of these genes in various eukaryotic systems. This review summarizes recent studies of the MCB element in yeast and briefly discusses the purpose of regulating DNA replication genes in the eukaryotic cell cycle.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.