ArticleMolecular and cellular biology1994
An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 100 citations in OpenAlex.
- Uncovering the molecular basis of kinase activity and substrate recognition with phospho-PCA.bioRxiv : the preprint server for biology · 2025Article
- Effects of heterologous kinase domains on growth factor receptor specificity.Cellular signalling · 2024Article
- Anti-tumor activity of motesanib in a medullary thyroid cancer model.Journal of endocrinological investigation · 2012Article
- Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells.Molecular and cellular biology · 2004Article
- Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury.Molecular neurobiology · 2003Review
- The EGF receptor family--multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4.Transactions of the American Clinical and Climatological Association · 2003Review
- The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.Molecular and cellular biology · 2002Article
- The sensitivity of activated Cys Ret mutants to glial cell line-derived neurotrophic factor is mandatory to rescue neuroectodermic cells from apoptosis.Molecular and cellular biology · 2001Article
- Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.The Journal of cell biology · 2001Article
- Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.Molecular and cellular biology · 2001Article
- Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis.Journal of medical genetics · 2000Review
- Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain.Molecular and cellular biology · 2000Article
- The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease.The EMBO journal · 2000Article
- Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.Molecular and cellular biology · 1998Article
- Shc and Enigma are both required for mitogenic signaling by Ret/ptc2.Molecular and cellular biology · 1998Article
- A potential pathogenetic mechanism for multiple endocrine neoplasia type 2 syndromes involves ret-induced impairment of terminal differentiation of neuroepithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Molecular heterogeneity of RET loss of function in Hirschsprung's disease.The EMBO journal · 1996Article
- Motogenic and morphogenic activity of epithelial receptor tyrosine kinases.The Journal of cell biology · 1996Article
- Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase.Molecular and cellular biology · 1996Article
- Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A chimeric expression vector which encoded for a molecule encompassing the extracellular domain of the epidermal growth factor (EGF) receptor (EGFR) and the intracellular domain of the ret kinase (EGFR/ret chimera) was generated. Upon ectopic expression in mammalian cells, the EGFR/ret chimera was correctly synthesized and transported to the cell surface, where it was shown capable of binding EGF and transducing an EGF-dependent signal intracellularly. Thus, the EGFR/ret chimera allows us to study the biological effects and biochemical activities of the ret kinase under controlled conditions of activation. Comparative analysis of the growth-promoting activity of the EGFR/ret chimera expressed in fibroblastic or hematopoietic cells revealed a biological phenotype clearly distinguishable from that of the EGFR, indicating that the two kinases couple with mitogenic pathways which are different to some extent. Analysis of biochemical pathways implicated in the transduction of mitogenic signals also evidenced significant differences between the ret kinase and other receptor tyrosine kinases. Thus, the sum of our results indicates the existence of a ret-specific pathway of mitogenic signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.