ArticleProceedings of the National Academy of Sciences of the United States of America1993
Polyoma virus early-late switch: regulation of late RNA accumulation by DNA replication.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Better late than never: A unique strategy for late gene transcription in the beta- and gammaherpesviruses.Seminars in cell & developmental biology · 2023Review
- Article
- Significant differences in terms of codon usage bias between bacteriophage early and late genes: a comparative genomics analysis.BMC genomics · 2017Article
- Article
- Review
- Global Analysis of Mouse Polyomavirus Infection Reveals Dynamic Regulation of Viral and Host Gene Expression and Promiscuous Viral RNA Editing.PLoS pathogens · 2015Article
- A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal Persistence.PLoS pathogens · 2015Article
- ADARs: viruses and innate immunity.Current topics in microbiology and immunology · 2012Review
- Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo.PLoS pathogens · 2012Article
- Article
- Gene regulation by sense-antisense overlap of polyadenylation signals.RNA (New York, N.Y.) · 2009Article
- RNA processing in the polyoma virus life cycle.Frontiers in bioscience (Landmark edition) · 2009Review
- Independent contributions of polyomavirus middle T and small T to the regulation of early and late gene expression and DNA replication.Journal of virology · 2006Article
- Induction of the human papillomavirus type 31 late promoter requires differentiation but not DNA amplification.Journal of virology · 2005Article
- Inhibition of polyomavirus ori-dependent DNA replication by mSin3B.Journal of virology · 2002Article
- Role of middle T-small T in the lytic cycle of polyomavirus: control of the early-to-late transcriptional switch and viral DNA replication.Journal of virology · 2001Article
- Kinetic analysis of the steps of the polyomavirus lytic cycle.Journal of virology · 2001Article
- Antisense RNA: function and fate of duplex RNA in cells of higher eukaryotes.Microbiology and molecular biology reviews : MMBR · 1998Review
- Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Characterization of two novel YY1 binding sites in the polyomavirus late promoter.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Early in infection of permissive mouse cells, messages from the early region of the polyoma virus genome accumulate preferentially over those from the late region. After initiation of DNA replication, the balance between early and late gene expression is reversed in favor of the late products. In previous work from our laboratory, we showed that viral early proteins do not activate the polyoma late promoter in the absence of DNA replication. Here we show that activation of the late genes in replication-incompetent viral genomes can occur if actively replicating genomes are present in the same cell. A low level of DNA replication, however, is insufficient to induce the early-late switch. Furthermore, replication-competent genomes that fail to accumulate late RNA molecules are defective in the transactivation of replication-incompetent genomes. We suggest that titration of an unknown diffusible factor(s) after DNA replication relieves the block to late RNA accumulation seen in the early phase, with most of this titration being attributable to late-strand RNA molecules themselves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.