ArticleMolecular and cellular biology1993
Pi, a pre-B-cell-specific enhancer element in the immunoglobulin heavy-chain enhancer.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator.Molecular and cellular biology · 1999Article
- Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family.Molecular and cellular biology · 1997Article
- Combinatorial determinants of tissue-specific transcription in B cells and macrophages.Molecular and cellular biology · 1997Article
- Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif.The EMBO journal · 1996Article
- Context dependent transactivation domains activate the immunoglobulin mu heavy chain gene enhancer.The EMBO journal · 1996Article
- Establishment and characterization of choroid plexus carcinoma cell lines: connection between choroid plexus and immune systems.Japanese journal of cancer research : Gann · 1996Article
- Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1.Molecular and cellular biology · 1996Article
- Pi 1 binding sites are negative regulators of bcl-2 expression in pre-B cells.Molecular and cellular biology · 1995Article
- Pax5 (BSAP) regulates the murine immunoglobulin 3' alpha enhancer by suppressing binding of NF-alpha P, a protein that controls heavy chain transcription.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate.Molecular and cellular biology · 1995Article
- ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have identified a new immunoglobulin heavy-chain enhancer element, designated pi, between the microE2 and microE3 elements. The pi enhancer element is transcriptionally active primarily during early stages of B-cell development but becomes virtually inactive during B-cell maturation at about the stage of immunoglobulin kappa light-chain gene rearrangement. Mutational analysis suggests that the pi element is crucial for immunoglobulin heavy-chain enhancer activity at the pre-B-cell stage but is almost irrelevant for enhancer activity at the mature B-cell or plasma-cell stage. The activity of the pi enhancer element correlates with the presence of an apparently pre-B-cell-specific protein-DNA complex. The similarity of the pi site to recognition sequences for members of the ets gene family suggests that the protein(s) interacting with the pi site most likely are ets-related transcription factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.