ArticleMolecular and cellular biology1993
Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 70 citations in OpenAlex.
- The Abundance and Availability of Cytokine Receptor IL-2Rβ (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Latent viruses can cause disease by disrupting the competition for the limiting factor p300/CBP.Cellular & molecular biology letters · 2018Review
- Expression of bovine interleukin 15 and evaluation of its biological activity in vitro.Veterinary world · 2015Article
- Review
- The possible functions of duplicated ets (GGAA) motifs located near transcription start sites of various human genes.Cellular and molecular life sciences : CMLS · 2011Article
- ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site.Cellular & molecular biology letters · 2010Article
- IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Identification of the DNA binding element of the human ZNF300 protein.Cellular & molecular biology letters · 2008Article
- Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity.Molecular and cellular biology · 2005Article
- The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity.The Journal of experimental medicine · 1998Article
- GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction.Molecular and cellular biology · 1997Article
- Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Establishment and characterization of choroid plexus carcinoma cell lines: connection between choroid plexus and immune systems.Japanese journal of cancer research : Gann · 1996Article
- Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interleukin-2 receptor (IL-2R) beta chain (IL-2R beta) is an essential signaling component of high- and intermediate-affinity IL-2Rs. Our laboratory previously reported that a DNA fragment containing 857 bp of 5'-flanking sequence of the human IL-2R beta gene exhibited promoter activity. We have now further characterized the promoter and delineated cis-acting regulatory regions. The region downstream of -363 is critical for basal and phorbol myristate acetate-inducible IL-2R beta promoter activity and contains at least three enhancer-like regions. Among them, the -56 to -34 enhancer was the most potent and had high-level activity in two T-cell lines but not in nonlymphoid HeLaS3 and MG63 cells. This enhancer contains a GGAA Ets binding site which bound two Ets family proteins, Ets-1 and GA-binding protein in vitro. Mutation of the Ets motif strongly diminished both promoter and enhancer activities. We conclude that this Ets binding site plays a key role in regulating basal and phorbol myristate acetate-inducible IL-2R beta promoter activity and may also contribute to tissue-specific expression of the IL-2R beta gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.