Trial reportKidney international1993
Baseline analysis of renal function in the Diabetes Control and Complications Trial. The Diabetes Control and Complications Trial Research Group [corrected].
Trial report in Kidney international, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02879409 (Does Glycated Hemoglobin Variability in Type 2 Diabetes Differ Depending on the Diabetes Treatment Threshold Used in the Qatari Population), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Does Glycated Hemoglobin Variability in Type 2 Diabetes Differ Depending on the Diabetes Treatment Threshold Used in the Qatari Population: Implication on Diabetes Complication Risk?
Who cites it
26 citing papers in PubMed, 74 citations in OpenAlex.
- Kidney disease and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study.Diabetes care · 2014Trial
- Equations to estimate creatinine excretion rate: the CKD epidemiology collaboration.Clinical journal of the American Society of Nephrology : CJASN · 2011Trial
- Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy.The New England journal of medicine · 2000Trial
- Increased small dense LDL and intermediate-density lipoprotein with albuminuria in type 1 diabetes.Diabetes care · 1999Trial
- Altered oxidant and antioxidant levels are associated with vascular stiffness and diabetic kidney disease in type 1 diabetes after exposure to acute and chronic hyperglycemia.Cardiovascular diabetology · 2024Article
- Urinary symptoms and female sexual dysfunction in women with type 1 diabetes: the role of depression.The journal of sexual medicine · 2023Article
- The many faces of diabetes. Is there a need for re-classification? A narrative review.BMC endocrine disorders · 2022Review
- Plasma advanced glycation end products and the subsequent risk of microvascular complications in type 1 diabetes in the DCCT/EDIC.BMJ open diabetes research & care · 2022Article
- Longitudinal patterns of urinary incontinence and associated predictors in women with type 1 diabetes.Neurourology and urodynamics · 2022Article
- Pyrroloquinoline quinone alleviates oxidative damage induced by high glucose in HepG2 cells.Saudi journal of biological sciences · 2021Article
- Autonomic neuropathy and urologic complications in diabetes.Autonomic neuroscience : basic & clinical · 2020Review
- Systemic factors related to soluble (pro)renin receptor in plasma of patients with proliferative diabetic retinopathy.PloS one · 2017Article
- Urogenital Autonomic Dysfunction in Diabetes.Current diabetes reports · 2016Review
- Cardiovascular Autonomic Neuropathy, Sexual Dysfunction, and Urinary Incontinence in Women With Type 1 Diabetes.Diabetes care · 2016Article
- Nanoceria Attenuated High Glucose-Induced Oxidative Damage in HepG2 Cells.Cell journal · 2016Article
- Multiphasic changes in systemic VEGF following intravitreal injections of ranibizumab in a child.Eye (London, England) · 2015Article
- Article
- Prevalence of systemic co-morbidities in patients with various grades of diabetic retinopathy.The Indian journal of medical research · 2014Article
- Effects of physical activity on the development and progression of microvascular complications in type 1 diabetes: retrospective analysis of the DCCT study.BMC endocrine disorders · 2013Article
- Alteration of pulmonary function in diabetic nephropathy.Journal of diabetes and metabolic disorders · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine whether there are relationships between nephropathy, retinopathy and putative risk factors at points very early in the development of long-term complications of IDDM, we have analyzed baseline data pertinent to nephropathy in the 726 subjects in the primary prevention cohort and the 715 subjects in the secondary intervention cohort of the DCCT. AER correlated positively with CCr and HbA1c in both cohorts and with degree of retinopathy and duration of IDDM in the secondary cohort. Within the secondary cohort only mean BP and HbA1c levels were significantly increased (P < 0.005) in the 73 subjects with AER > or = 28 micrograms/24 hr compared to the 642 subjects with AER < 28 micrograms/24 hr. Stratification of all subjects in the secondary cohort showed significant associations (P < 0.001) between retinopathy level, AER, duration of diabetes at entry and entry HbA1c. Even very early in the development of retinopathy and nephropathy, there is a relationship between them and with level of metabolic control. The prospective studies of the DCCT are designed to answer the question of whether intensive diabetes treatment will affect the development and/or progression of retinopathy, and, possibly, of nephropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.