ArticleMolecular and cellular biology1996
Transcriptional down regulation of the nov proto-oncogene in fibroblasts transformed by p60v-src.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 86 citations in OpenAlex.
- Time has come to address the spatiotemporal combinatorial model for CCN proteins biological activitites by spatial transcriptomics and genome wide association studies.Journal of cell communication and signaling · 2023Article
- Article
- Src promotes castration-recurrent prostate cancer through androgen receptor-dependent canonical and non-canonical transcriptional signatures.Oncotarget · 2017Article
- CCN proteins: A centralized communication network.Journal of cell communication and signaling · 2013Article
- Genome-wide differential gene expression in immortalized DF-1 chicken embryo fibroblast cell line.BMC genomics · 2011Article
- Cellular processes of v-Src transformation revealed by gene profiling of primary cells--implications for human cancer.BMC cancer · 2010Article
- Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src.Virology · 2007Article
- NOV story: the way to CCN3.Cell communication and signaling : CCS · 2006Article
- Integration of Myeloblastosis Associated Virus proviral sequences occurs in the vicinity of genes encoding signaling proteins and regulators of cell proliferation.Cell communication and signaling : CCS · 2006Article
- Potential cellular conformations of the CCN3(NOV) protein.Cell communication and signaling : CCS · 2004Article
- The expression of ccn3(nov) gene in musculoskeletal tumors.The American journal of pathology · 2002Article
- Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV).Molecular pathology : MP · 2001Article
- Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues.Molecular pathology : MP · 2001Article
- The expression of ccn3 (nov) RNA and protein in the rat central nervous system is developmentally regulated.Molecular pathology : MP · 2001Article
- NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues.Molecular pathology : MP · 2001Review
- Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo.Molecular and cellular biology · 1999Article
- Nuclear localisation of NOVH protein: a potential role for NOV in the regulation of gene expression.Molecular pathology : MP · 1999Article
- The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation.Molecular and cellular biology · 1998Article
- novH: differential expression in developing kidney and Wilm's tumors.The American journal of pathology · 1998Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
We have sought to identify genes whose expression is altered as a consequence of transformation by p60v-src. Using the mRNA differential display method, we have identified the nov proto-oncogene as one gene that is down regulated in chicken embryo fibroblasts (CEFs) transformed by p60v-src. nov transcripts were also found to be present at only very low levels in proliferating CEFs in comparison with quiescent CEFs. Serum stimulation of quiescent CEFs also resulted in a decline in the steady-state level of nov transcripts. Taken together, these findings suggest that the nov gene is expressed only in quiescent fibroblasts and that its down regulation may contribute to cellular transformation by the v-src oncogene. Down regulation of the nov gene appears to occur at both the transcriptional and posttranscriptional levels. Results obtained from experiments with a protein kinase inhibitor suggest that protein kinase C may be a key downstream effector in mediating the down regulation of nov transcripts in response to activation of p60src or serum stimulation. In addition, we found that transcription of an unknown gene is required for the decline in the steady-state level of nov transcripts in response to serum stimulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.