Evidence map›Paper›PMID 8569826›Full record

ReviewThe New England journal of medicine1996

Metformin.

C J Bailey, R C Turner

5 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in The New England journal of medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 546 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
546citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00941161 phase4completedstarted 2009, after this paper: background citation

Effect of Oral Combination Therapy of Metformin Extended Release Over Glimepiride in a Single Dosage Form in Patients With Type 2 Diabetes Mellitus With Failure of Monotherapy

Ran2009Enrolled28Registered outcomes2Posted comparisons0ConditionsType 2 Diabetes MellitusArmsGlimepiride, Metformin, metformin/glimepiride combination
PMID 10764846PMID 15612515PMID 16567811PMID 17414590PMID 17065711PMID 11336617PMID 8911975PMID 17666882PMID 16802130PMID 16751851PMID 10520820other papers from this trial
Open the trial in the graph
NCT03031821 phase3terminatedstarted 2018, after this paper: background citation

A Randomized Phase 3 Trial of Metformin in Patients Initiating Androgen Deprivation Therapy as Prevention and Intervention of Metabolic Syndrome: The Prime Study

Ran2018Enrolled166Registered outcomes30Posted comparisons0ConditionsMetabolic Syndrome, Prostate CancerArmsMetformin, Placebo Oral Tablet
PMID 21933330PMID 20452916PMID 26633628PMID 9742977PMID 25017630PMID 23230096PMID 25456737PMID 24412228PMID 25536258PMID 23918942PMID 15838067PMID 7821128other papers from this trial
Open the trial in the graph
NCT04766008 phase4unknown statusstarted 2020, after this paper: background citation

Metformin Continuation Safety in Diabetic Patients Undergoing Coronary Angiography

Ran2020Enrolled150Registered outcomes4Posted comparisons0ConditionsContrast-induced Nephropathy, Coronary Artery Disease, Diabetes Mellitus, Lactic Acidosis With Diabetes MellitusArmsMetformin
PMID 9630271PMID 21959259PMID 15338847PMID 31553855PMID 15808754PMID 17692741PMID 19797290PMID 30667361other papers from this trial
Open the trial in the graph
NCT01437800 phase1completednot on this mapstarted 2011, after this paper: background citation

Bioavailability of Glimepiride/Extended Release Metformin (4/850 mg) in Healthy Mexican Volunteers

TypeinterventionalSponsorLaboratorios Silanes S.A. de C.V.Ran2011 to 2011Enrolled24ConditionsHealthyArmsGlimepiride / Extended release Metformin (4/850 mg).
NCT01437813 phase1completednot on this mapstarted 2011, after this paper: background citation

Bioavailability of Glimepiride/Extended Release Metformin (4/850 mg) After a High Fat Diet, in Healthy Mexican Volunteers

TypeinterventionalSponsorLaboratorios Silanes S.A. de C.V.Ran2011 to 2011Enrolled24ConditionsHealthyArmsGlimepiride/ Extended release Metformin
3 · Its place in the literature

Who cites it

546 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Metformin versus insulin in gestational diabetes mellitus: a systematic review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024
    Pooled it
  4. Pooled it
  5. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
  6. Pooled it
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  12. Trial
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486 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

C J BaileyDepartment of Pharmaceutical and Biological Sciences, Aston University, Birmingham, United Kingdom.
R C Turner

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acidosis, LacticDiabetes Mellitus, Type 2Drug Therapy, CombinationHumansHypoglycemic AgentsMetforminSulfonylurea CompoundsHypoglycemic AgentsMetforminSulfonylurea Compounds

Identifiers

PMID8569826

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.