ArticleThe American journal of physiology1995
Insulin increases blood volume in human skeletal muscle: studies using [15O]CO and positron emission tomography.
Article in The American journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02633488 (Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome), which is not on this map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome
Who cites it
12 citing papers in PubMed, 55 citations in OpenAlex.
- Quantitative analysis of the postcontractile blood-oxygenation-level-dependent (BOLD) effect in skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Trial
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- Repeatability of [EJNMMI research · 2024Article
- Total-Body Perfusion Imaging with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium.Current pharmaceutical design · 2020Review
- Article
- Exercise resistance across the prediabetes phenotypes: Impact on insulin sensitivity and substrate metabolism.Reviews in endocrine & metabolic disorders · 2016Review
- The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action.Endocrine reviews · 2010Review
- The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action.Diabetologia · 2009 · on this mapReview
- Comparison of three physiologically-based pharmacokinetic models for the prediction of contrast agent distribution measured by dynamic MR imaging.Journal of magnetic resonance imaging : JMRI · 2008Article
- Prediction of the rate of uptake of carbon monoxide from blood by extravascular tissues.Respiratory physiology & neurobiology · 2008Article
- Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers.Diabetologia · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High insulin concentrations increase blood flow in the leg, but it is unknown whether this effect is associated with a change in muscle blood volume. In the present study, we used positron emission tomography combined with inhalation of [15O]carbon monoxide to quantitate the effect of insulin on skeletal muscle blood volume in humans. The reproducibility of the method was determined from two consecutive measurements performed in the basal state in five normal subjects. The coefficient of variation of the repeated measurements was 3.0 +/- 1.8%. In 14 normal subjects [age 35 +/- 3 yr, body mass index 24.9 +/- 1.3 (SE) kg/m2], skeletal muscle blood volume was determined in the femoral region in the basal state and during euglycemic hyperinsulinemia (serum insulin 3,200 +/- 190 pmol/l). The mean muscle blood volume was 3.3 +/- 0.1 ml/0.1 kg muscle in the basal state. Insulin increased muscle blood volume by 9 +/- 2% to 3.6 +/- 0.2 ml/0.1 kg muscle (P < 0.01). The rate of whole body glucose uptake was 53 +/- 6 mumol.kg-1.min-1 and correlated with muscle blood volume during insulin stimulation (r = 0.65, P < 0.02). We conclude that high insulin concentrations exert a true vasodilatory effect in human skeletal muscle.
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