ArticleAmerican journal of human genetics1996
Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 121 citations in OpenAlex.
- Genetics of bipolar disorder.Dialogues in clinical neuroscience · 2008Review
- Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains.Genetics · 2005Article
- Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q.American journal of human genetics · 2005Article
- Genetics of major mood disorders.Psychiatry (Edgmont (Pa. : Township)) · 2004Article
- Review of bipolar molecular linkage and association studies.Current psychiatry reports · 2002Review
- Genetics of bipolar affective disorder.Current psychiatry reports · 2000Review
- Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype.American journal of human genetics · 2000Article
- Genetics of bipolar disorder.Journal of medical genetics · 1999Review
- Molecular linkage studies of bipolar disorder.Dialogues in clinical neuroscience · 1999Article
- Bipolar disorder.Dialogues in clinical neuroscience · 1999Article
- A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus.American journal of human genetics · 1999Article
- A susceptibility locus for bipolar affective disorder on chromosome 4q35.American journal of human genetics · 1998Article
- Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series.American journal of human genetics · 1997Article
- The genetic epidemiology of psychiatric disorders: a current perspective.Social psychiatry and psychiatric epidemiology · 1997Review
- A follow-up report of a genome search for affective disorder predisposition loci in the Old Order Amish.American journal of human genetics · 1996Article
- Genetic dissociation of acquisition and memory strength in the heat-box spatial learning paradigm in Drosophila.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region between D21S270 and D21S171, with excess allele sharing (nominal P values <.01) under two affection-status models, ASM I (bipolars and schizoaffectives) and ASM II (ASM I plus recurrent unipolars). In addition, under ASM I, the proximal interval spanned by D21S1436 and D21S65 showed locus trios with excess allele sharing (nominal P values of .03-.0003). These findings support prior evidence that a susceptibility locus for bipolar disorder is on 21q.
Indexed as
Identifiers
8651306PMC1915054W1589573948What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.