ReviewJournal of electron microscopy1996
Glucose transporters in the transepithelial transport of glucose.
Review in Journal of electron microscopy, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02694263 (A Randomised Controlled Trial for People With Established Type 2 Diabetes During Ramadan), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomised Controlled Trial for People With Established Type 2 Diabetes During Ramadan: Canagliflozin (Invokana™) vs. Standard Dual Therapy Regimen: The 'Can Do Ramadan' Study
Who cites it
25 citing papers in PubMed, 101 citations in OpenAlex.
- Immunolocalization of Na(+)-Dependent Glucose Co-Transporters in Chicken Kidneys in Norm and During T-2 Mycotoxicosis (Primary Study).Current issues in molecular biology · 2024Article
- Plant-derived cell-penetrating microprotein α-astratide aM1 targets Akt signaling and alleviates insulin resistance.Cellular and molecular life sciences : CMLS · 2023Article
- Profiling neuroprotective potential of trehalose in animal models of neurodegenerative diseases: a systematic review.Neural regeneration research · 2023Review
- Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2.JCI insight · 2023Article
- Review
- A mathematical model of GLUT1 modulation in rods and RPE and its differential impact in cell metabolism.Scientific reports · 2022Article
- Glut1 deficiency syndrome: New and emerging insights into a prototypical brain energy failure disorder.Neuroscience insights · 2021Review
- A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect.Clinical medicine insights. Endocrinology and diabetes · 2021Review
- Immunohistochemical Study of Glucose Transporter GLUT-5 in Duodenal Epithelium in Norm and in T-2 Mycotoxicosis.Foods (Basel, Switzerland) · 2020Article
- Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells.American journal of physiology. Cell physiology · 2019Article
- Deletion of GLUT1 in mouse lens epithelium leads to cataract formation.Experimental eye research · 2018Article
- Expression of glucose transporters in the developing rat skin.Anatomy & cell biology · 2017Article
- The effect of metformin treatment in vivo on acute and long-term energy metabolism and progesterone production in vitro by granulosa cells from women with polycystic ovary syndrome.Human reproduction (Oxford, England) · 2014Article
- Decreased basal chloride secretion and altered cystic fibrosis transmembrane conductance regulatory protein, Villin, GLUT5 protein expression in jejunum from leptin-deficient mice.Diabetes, metabolic syndrome and obesity : targets and therapy · 2014Article
- Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma.International journal of oncology · 2012Article
- Functional role of sodium glucose transporter in high glucose-mediated angiotensin type 1 receptor downregulation in human proximal tubule cells.American journal of physiology. Renal physiology · 2012Article
- SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects.Nature reviews. Endocrinology · 2012 · on this mapReview
- Glucose transporters are expressed in taste receptor cells.Journal of anatomy · 2011Article
- The inhibition of lipase and glucosidase activities by acacia polyphenol.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Glucose transporter Glut-1 is detectable in peri-necrotic regions in many human tumor types but not normal tissues: Study using tissue microarrays.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally-related substances across the cellular membranes. Two families of glucose transporter have been identified: the facilitated-diffusion glucose transporter family (GLUT family), and the NA(+)-dependent glucose transporter one (SGLT family). These transporters play a pivotal role in the transfer of glucose across the epithelial cell layers that separate distinct compartments in the mammalian body. In the small intestine, a Na(+)-dependent glucose transporter, SGLT1, is localized at the apical plasma membrane of the absorptive epithelial cells, whereas a facilitated-diffusion glucose transporter, GLUT2, is at the basolateral membrane of the cells. Similar localization is seen in the kidney proximal tubules in the reabsorption of glucose. For the absorption of fructose in the small intestine, fructose transporter GLUT5 is localized at the apical membrane. The expressed GLUT5 in polarized cultured cells is targeted to the apical membrane, showing that the GLUT5 molecule itself has sufficient information to determine its cellular localization. In the blood-tissue barriers, such as the blood-brain barrier, blood-ocular barrier, and placental barrier, either endothelial or epithelial cell layers constitute the barrier. GLUT1 is abundant at the plasma membrane of these barrier cells, and plays a crucial role in the specific transfer of glucose across the barrier. When the barrier is composed of a two-cell layer, gap junctions connecting them could serve as intercellular channels for glucose transfer in addition to GLUT1. Proper localization of glucose transporters and gap junctions is a prerequisite for the successful transepithelial transport of sugars.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.