Trial reportThe Journal of physiology1996
Relationship between limb and muscle blood flow in man.
Trial report in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Sodium nitroprusside increases human skeletal muscle blood flow, but does not change flow distribution or glucose uptake.The Journal of physiology · 1999Trial
- Human calf precapillary resistance decreases in response to small cumulative increases in venous congestion pressure.The Journal of physiology · 1998Trial
- Quantification of Skeletal Muscle Perfusion in Feet and Lower Legs of Patients with T2DM and Diabetic Foot Ulcers Using [Journal of clinical medicine · 2025Article
- Validity of leptin receptor-deficiency (db/db) type 2 diabetes mellitus mice as a model of secondary osteoporosis.Scientific reports · 2016Article
- An Actively Decoupled Dual Transceiver Coil System for Continuous ASL at 7 T.International journal of imaging systems and technology · 2016Article
- Positron emission tomography detects greater blood flow and less blood flow heterogeneity in the exercising skeletal muscles of old compared with young men during fatiguing contractions.The Journal of physiology · 2014Article
- Noncontrast skeletal muscle oximetry.Magnetic resonance in medicine · 2014Article
- Regional differences in blood flow, glucose uptake and fatty acid uptake within quadriceps femoris muscle during dynamic knee-extension exercise.European journal of applied physiology · 2013Article
- Dynamic Fluid Flow Mechanical Stimulation Modulates Bone Marrow Mesenchymal Stem Cells.Bone research · 2013Article
- SPECT/CT-plethysmography--non-invasive quantitation of bone and soft tissue blood flow.Journal of orthopaedic surgery and research · 2008Article
- Insulin and contraction increase nutritive blood flow in rat muscle in vivo determined by microdialysis of L-[14C]glucose.The Journal of physiology · 2007Article
- Article
- Insulin signalling and resistance in patients with chronic heart failure.The Journal of physiology · 2003Article
- Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and redistribution, but not of glucose uptake in non-insulin-dependent diabetes mellitus.The Journal of clinical investigation · 1997Article
- Peripheral limitations of maximal aerobic capacity in patients with chronic heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Since direct measurement of muscle blood flow in humans has been difficult, estimations of muscle flow have been made from measured total limb blood flow using a classic equation that predicts that the fraction of resting blood flow through muscle tissue decreases as total limb flow increases. 2. We used positron emission tomography and 15O-labelled water to directly quantify resting muscle and total limb blood flow in cross-sections of the femoral region in twenty-eight normal subjects (age, 30 +/- 8 years; body mass index, 24.1 +/- 3.3 Kg m-2) under conditions of constant environmental temperature of 22-23 degrees C. 3. Muscle blood flow averaged 3.1 +/- 1.7 ml (100 ml muscle)-1 min-1 (range, 1.1-7.5 ml (100 ml muscle)-1 min-1 and cross-sectional limb blood flow averaged 2.5 +/- 1.1 ml (100 ml limb)-1 min-1) (range, 1.0-4.8 ml (100 ml limb)-1 min-1). A linear relationship was observed between limb and muscle blood flow, and a regression equation was calculated for estimation of muscle blood flow bases on limb flow: muscle flow = (1.41 +/- 0.10) limb flow - (0.43 +/- 0.28). The slope of this equation was significantly greater than 1 (P < 0.001) indicating that the fraction of blood flow perfusing muscle tissue increases as a function of total limb flow. 4. These data provide a new equation for estimation of resting muscle blood flow in normal subjects, and demonstrate that muscle blood flow is the primary determinant of resting blood flow in man.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.