Evidence map›Paper›PMID 8994419›Full record

ArticleCirculation1997

Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Québec Cardiovascular Study.

B Lamarche, A Tchernof, S Moorjani, B Cantin, G R Dagenais, P J Lupien, J P Després

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Circulation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01384058 (The Effect of Ezetimibe 10 mg, Simvastatin 20 mg and the Combination of Simvastatin 20 mg Plus 10 mg Ezetimibe on Low Density Lipoprotein), which is not on this map. Cited by 204 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
204citing papers in PubMed, 10 pooled it
52.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01384058 phase4completedstarted 2007, after this paper: background citation

The Effect of Ezetimibe 10 mg, Simvastatin 20 mg and the Combination of Simvastatin 20 mg Plus 10 mg Ezetimibe on Low Density Lipoprotein (LDL)-Subfractions in Patients With Type 2 Diabetes

Ran2007Enrolled41Registered outcomes5Posted comparisons0ConditionsDiabetes Mellitus Type 2, HypercholesterolemiaArmsEzetimibe, Ezetimibe 10/Simvastatin 20, simvastatin
PMID 12466341PMID 15146369PMID 1832551PMID 12370215PMID 8429263PMID 8325978PMID 8060384PMID 7981955PMID 5009984PMID 2372896PMID 1770294PMID 14350806other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

204 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,086 citations in OpenAlex.

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  10. Treatment of lipids and type 2 diabetes.Current cardiology reports · 2004
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144 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

B LamarcheLipid Research Center, CHUL Research Center, Ste-Foy, Québec, Canada.
A Tchernof
S Moorjani
B Cantin
G R Dagenais
P J Lupien
J P Després
Jisc · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCase-control studies have reported that patients with ischemic heart disease (IHD) have a higher proportion of small, dense LDL particles than do healthy control subjects. The extent to which the risk attributed to small LDL particles may be independent of concomitant variations in plasma lipoprotein-lipid concentrations remains to be clearly determined, however, particularly through prospective studies. METHODS AND

resultsBaseline characteristics were obtained in 2103 men initially free of IHD, among whom 114 developed IHD during a 5-year follow-up period. These 114 case patients were matched with healthy control subjects for age, body mass index, smoking habits, and alcohol intake. LDL peak particle diameter (PPD) was measured a posteriori in 103 case-control pairs by nondenaturing gradient gel electrophoresis of whole plasma. Conditional logistic regression analysis of the case-control status revealed that men in the first tertile of the control LDL-PPD distribution (LDL-PPD < or = 25.64 nm) had a 3.6-fold increase in the risk of IHD (95% CI, 1.5 to 8.8) compared with those in the third tertile (LDL-PPD > 26.05 nm). Statistical adjustment for concomitant variations in LDL cholesterol, triglycerides, HDL cholesterol, and apolipoprotein B concentrations had virtually no impact on the relationship between small LDL particles and the risk of IHD.

conclusionsThese results represent the first prospective evidence suggesting that the presence of small, dense LDL particles may be associated with an increased risk of subsequently developing IHD in men. Results also suggest that the risk attributed to small LDL particles may be partly independent of the concomitant variation in plasma lipoprotein-lipid concentrations.

Indexed as

AdultApolipoproteins BCase-Control StudiesCholesterol, HDLCholesterol, LDLHumansLogistic ModelsMaleMiddle AgedMyocardial IschemiaOdds RatioParticle SizeProspective StudiesRisk FactorsTriglyceridesApolipoproteins BCholesterol, HDLCholesterol, LDLTriglycerides

Identifiers

PMID8994419
OpenAlexW2152086330

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.